PhD offer within the In vivo Organ Generation by Stem Cells group, CIMA Universidad de Navarra,[...]

Cima Universidad de Navarra; Pamplona; Presencial; EUR 18.000 - 25.000; Jornada completa

Descripción de la vacante

A leading research institution in Spain is seeking a highly motivated PhD student to join the In vivo Organ Generation by Stem Cells Group. The candidate will apply cutting-edge genomic technologies in a collaborative international environment. Candidates should have a degree in relevant sciences and be enrolled in a Master's program. Knowledge of Computational Biology/Bioinformatics is a plus.

Formación

• Must have a University degree in a relevant field.
• Creative, ambitious, and highly motivated traits are essential.
• Currently enrolled in a Master's program or already completed.

Responsabilidades

• Join a collaborative environment with an international team.
• Apply cutting-edge genomic technologies in Biomedical Engineering.

Conocimientos

Creativity

Ambition

Motivation

Knowledge on Computational Biology / Bioinformatics

Educación

University degree in Sciences (Biology, Biochemistry, Pharmacy, Biotechnology…) with at least 8/10 marks

Current enrollment in a Master's program granting access to doctoral studies

Descripción del empleo

The In vivo Organ Generation by Stem Cells Group, led by Dr. Xabier Aranguren is looking for a candidate to carry out the doctoral thesis for the 26/27 academic year.

Organ transplantation is a very effective life-saving treatment for end-stage organ diseases. Nevertheless the number of organs available for transplantations is limited, and the waiting lists are ever increasing, recently counting around 150.000 people Europe and 100.00 in USA, leading to a high rate of death for organ failure: only in the European continent, approximately 5.000 people die every year waiting for an organ, with a mortality rates for patients waiting for a heart, liver or lung ranging between 15 and 30%. The necessity to find additional source of organs for transplantation has boosted research on the generation of organs from pluripotent stem cells (PSCs).

We develop new therapeutic alternatives based on the generation of xeno-organs in vivo by blastocyst complementation using pluripotent stem cells. This strategy is based on the microinjection of stem cells into genetically modified embryos, incapable of generating a certain type of organ/cell type. In this way the target organ is formed exclusively from the microinjected stem cells. The group works with mouse and rat embryonic stem cells and human iPS cells, as well as with genetically modified mouse and pig models.

Last Publications

• https://pubmed.ncbi.nlm.nih.gov/40551151/
• https://pubmed.ncbi.nlm.nih.gov/37967560/
• https://pubmed.ncbi.nlm.nih.gov/37660554/
• https://pubmed.ncbi.nlm.nih.gov/36563688/
• https://pubmed.ncbi.nlm.nih.gov/35883376/

Requirements

The In vivo Organ Generation by Stem Cells Group, led by Dr. Xabier Aranguren, is seeking for a creative, ambitious and highly motivated candidate to joint as a PhD student. The candidate will join a highly collaborative environment with the opportunity to apply cutting-edge genomic technologies on the field of Biomedical Engineering. The work will be in permanent collaboration with an interactive international team of basic and translational. The candidate must have a University degree in Sciences (Biology, Biochemistry, Pharmacy, Biotechnology…) with at least 8/10 marks (For those studies outside of Spain, we would need the equivalent marks through https://universidades.sede.gob.es/pagina/index/directorio/Equivalencia_notas_medias/language/en). Moreover, the candidate must be currently enrolled in a Master's program that grants access to doctoral studies, with a planned completion date of September/October 2026, or already completed in 2025. Knowledge on Computational Biology / Bioinformatics will be valued.