PhD Student - Industrial Downstream Processing of Adeno-Associated Viral Vectors

Roche; Penzberg; Vor Ort; EUR 200.000 +; Vollzeit

Zusammenfassung

A leading pharmaceutical company in Penzberg is seeking a motivated PhD Student to work on the industrial downstream processing of viral vectors. The role involves developing purification technologies and improving manufacturing processes. Candidates should have a Master's degree in relevant fields and experience in downstream processing. The position offers flexibility and a monthly compensation of €3,750, along with various employee benefits.

Leistungen

Flexible working hours

€3,750 monthly compensation

Discounted meals

Access to fitness center

Networking opportunities

Qualifikationen

• Experience in downstream processing and analytics is required.
• Familiarity with virus vector technologies or therapeutic proteins is preferred.
• Motivated to work in a dynamic and challenging environment.

Aufgaben

• Develop and implement purification technologies for viral vector manufacturing.
• Identify and understand novel technologies in mixed-mode chromatography.
• Improve process productivity and manufacturability.
• Collaborate with internal and external partners.
• Publish findings in peer-reviewed journals.

Kenntnisse

Downstream processing

Robotic systems

Mixed-mode chromatography

Research publication

Collaboration

Ausbildung

Master Degree in Chemistry, Chemical Engineering, Biotechnology, or Biochemistry

Jobbeschreibung

PhD Student - Industrial Downstream Processing of Adeno-Associated Viral Vectors

Join to apply for the PhD Student - Industrial Downstream Processing of Adeno-Associated Viral Vectors role at Roche

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The Position

PhD Student for viral vector purification, Penzberg Site (PTCG DSP Development)

About The Department

We are dedicated to bringing game-changing viral vector-based Gene therapies from early clinical supply to market, addressing the unmet clinical need of patients to cure diseases. Our core mission is to develop safe, innovative, and effective therapies using cutting-edge technology across the entire value chain. Within the Cell and Gene Therapies area of the Pharma division, our daily work is characterized by the drive to develop world-class rAAV manufacturing processes.

The Project

This PhD project, situated within Roche’s Pharmaceutical Cell & Gene Therapy unit, aims to address the challenges in developing safe and effective purification processes for gene therapies (GT) using adeno-associated viruses (AAVs) as vectors. The project focuses on mixed-mode chromatographic technologies and their implementation into a robust, industrial purification process by understanding the dependencies on other purification steps, and impacting the GT’s quality, safety, and efficacy.

Your Responsibilities

• Develop and implement purification technologies that enhance manufacturing processes for viral vectors, with a focus on rAAVs by using robotic and benchtop systems
• Identify, characterize, and fully understand novel technologies related to mixed-mode chromatographic techniques for viral vector purification
• Develop strategies to improve overall process productivity and ensure manufacturability
• Proactively execute projects with internal and external partners and develop your own ideas. Support laboratory and pilot plant work through the transfer of practical skills and collaboration with technicians. Supervise students supporting the project
• Publish research findings in peer-reviewed journals and present at scientific conferences to contribute to the scientific community and enhance the organization's visibility

Your Profile

• You hold a Master Degree excellent qualifications in Chemistry, Chemical Engineering, Biotechnology, Biochemistry, or a related field, coupled with experience in the downstream processing and analytics
• Ideally, you have some experience in the field of virus vector technologies or therapeutic proteins, including small-scale production and process development
• You are highly motivated and are willing to work on challenging projects in a continuously progressing field, also requiring detailed investigations
• You are a strong team player, appreciate autonomous working with excellent planning and organizational skills
• You foster a collaborative and trusting relationship and enjoy working in an international environment

Your Benefits

• Flexible working hours
• €3,750 monthly compensation for a full-time internship longer than 3 months
• Discounted meals (–50%) in our staff cafeteria
• Access to the fitness center on the Roche campus
• Networking opportunities with other students

Your Application

Please upload only your CV online.

This PhD position is offered in collaboration with the Technical University of Mannheim. Please consider whether you can pursue your doctoral studies at this university.

Period: by arrangement, for a duration of 3 years (with a possibility of extension)

We look forward to receiving your application!

Roche is an Equal Opportunity Employer.