Senior Scientist (Inflammation and Immunology, EDDC)

Agency for Science, Technology and Research (A*STAR); Singapore; On-site; SGD 60,000 - 80,000; Full time

Job summary

A leading research agency in Singapore is seeking an experienced Senior Scientist to join their immunology discovery group. The successful candidate will lead preclinical research programs and develop innovative drug discovery methods. A Ph.D. in a relevant field with over 8 years of experience is required, including at least 3 years in the industry. This role offers a dynamic environment with opportunities for scientific innovation and collaboration with multidisciplinary teams.

Qualifications

• More than 8 years of working experience in relevant areas.
• Minimum of 3 years in the industry sector.
• Proven expertise in developing and optimizing cell-based functional assays.

Responsibilities

• Lead and design preclinical research programs focused on therapeutic targets in immunology.
• Develop and optimize cell-based assays and flow cytometry panels.
• Analyze and present complex data to internal and external stakeholders.

Skills

Immunology

Molecular Biology

Translational Research

Cell Biology

Data Analysis

Collaboration

Education

Ph.D. in Immunology, Cell Biology, Molecular Biology or related field

Tools

Bioinformatics tools

Job description

At Experimental Drug Development Centre (EDDC), we are dedicated to discovering and developing novel therapeutics through close collaboration with public sector institutions and industry partners. Drug discovery is a complex and resource-intensive journey, and we harness AI and data-driven strategies to improve the success rate of our programs. As part of our long-term strategy, we initiate projects where confidence in the therapeutic targets is strengthened by insights from patient-derived datasets. Like many biotech and pharmaceutical companies that are expanding into inflammation and immunology (I&I) disease areas, our approach reflects this growing trend and aims to deliver innovative solutions to address significant unmet medical needs in this area.

We are seeking a highly motivated and experienced Senior Scientist to join our I&I discovery group. The ideal candidate will have a strong background in immunology, molecular biology, and translational research. This is an exciting opportunity to be a part of the team working on the discovery of novel therapeutics and engaging in preclinical drug development from target exploration to drug candidate selection within the I&I therapeutic space.

Principle Roles & Responsibilities

• Lead and design preclinical research programs focused on identifying and validating novel therapeutic targets in immunology.
• Develop and optimize cell-based assays, flow cytometry panels, and molecular biology techniques to support drug discovery.
• Participate in the evaluation of internal as well as external collaborative projects.
• Analyze, interpret, and present complex data to internal stakeholders and external partners.
• Stay up to date with relevant scientific literature, research on translatability of preclinical disease models and novel mechanisms of action of particular importance within the I&I therapeutic space.
• Collaborate with cross-functional teams including medicinal chemistry, antibody technology, in vivo pharmacology, computational biology and clinical development.
• Mentor and train junior scientists, providing technical guidance, fostering scientific development, and supporting career growth within the team.

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or related field with > 8 years working experience and minimally 3 years experience in the industry sector.
• Strong expertise in immune cell biology, cytokine signalling, and autoimmune disease models.
• Experience with primary human PBMCs, along with a strong understanding of tissue repair and regeneration in the context of immune resolution.
• Proven expertise in developing and optimizing cell-based functional assays.
• Excellent communication and presentation skills, with the ability to clearly convey scientific concepts and influence stakeholders across multidisciplinary teams.
• Proven track record of scientific innovation, publications, and project leadership.
• Ability to work independently and collaboratively in a fast-paced, dynamic environment.

• Experience with biologics or small molecule therapeutics is preferred.
• Familiarity with bioinformatics tools and multi-omics data analysis is preferred.