Technical Associate I, Langer Lab

Massachusetts Institute of Technology- Koch Institute; Cambridge; On-site; GBP 30,000 - 60,000; Full time

Job summary

An innovative research institute is seeking a Technical Associate I to join a dynamic team focused on developing cutting-edge injectable drug delivery systems. This role offers the opportunity to work on exciting projects involving mRNA-lipid nanoparticles, where you'll engage in fabricating and characterizing drug delivery materials while conducting rigorous testing with animal models. If you're passionate about advancing the field of cancer research and have a strong background in biological sciences or engineering, this position is perfect for you. Join a collaborative environment where your skills will contribute to groundbreaking advancements in therapeutics.

Qualifications

• Minimum of two years relevant lab experience, including undergraduate experience.
• Willingness to work with animals and strong organizational skills.

Responsibilities

• Developing and characterizing lipid nanoparticles for drug delivery.
• Conducting animal studies and performing in-vivo imaging.

Skills

Drug Delivery

Biomaterials

Molecular Biology

Documentation Skills

Problem-Solving Skills

Education

Bachelor's degree in Biological Sciences

Master's degree in a Relevant Field

Tools

DLS

TEM

NMR

HPLC

qPCR

ELISA

Fluorescence Imaging

Job description

Posting Description

TECHNICAL ASSOCIATE I, Koch Institute for Integrative Cancer Research (KI) - Langer Lab, is seeking to join the Jaklenec Group to develop injectable drug delivery systems for vaccines and therapeutics, focusing on mRNA-lipid nanoparticles. Responsibilities include designing, fabricating, and characterizing drug delivery materials, conducting rigorous testing using animal models, and performing various analyses.

The role involves:

1. Fabrication & characterization: developing and characterizing lipid nanoparticles using DLS, TEM, NMR, zeta potential analysis, and HPLC.
2. Assessing mRNA stability and loading capacity.
3. Animal studies: administering injections (intradermal, subcutaneous, intramuscular, intraperitoneal) in mice and rats.
4. Performing in-vivo imaging and analyzing bio-samples (blood, tissue, organ homogenates) using qPCR, ELISA, and fluorescence imaging.

Job Requirements

REQUIRED: Bachelor's degree in biological sciences, material science, engineering, or related field; minimum of two years of relevant lab experience, including undergraduate experience; willingness to work with animals; experience in drug delivery, biomaterials, molecular biology, or related fields; strong documentation, organizational, and problem-solving skills.

PREFERRED: Master's degree in a relevant field; experience with histology, flow cytometry, micro molding, lipid nanoparticle synthesis, and drug delivery material characterization.

Job #24904

Application deadline: 4/4/2025