Senior Scientist - Downstream Analytics

Cranleigh Scientific; Havant; On-site; GBP 42,000 - 50,000; Full time

Job summary

A leading scientific organization in the UK is seeking a Senior Scientist to lead downstream analytical workflows, focusing on HPLC and bioprocessing. This on-site role in Southampton offers a salary up to £50,000 along with comprehensive benefits, including 25 days of annual leave, flexible working hours, and pension contributions. Ideal candidates will hold a PhD and possess strong experience with analytical techniques and quality compliance, along with strong communication skills.

Benefits

25 days annual leave + 8 bank holidays

6% employer pension contribution

Life Assurance: 4x salary

Flexible working hours

Cycle to work scheme

Gym discounts

Qualifications

• Strong hands-on experience in HPLC and bioprocessing.
• Solid grounding in downstream analytical techniques.
• Experience in ISO or GMP-regulated environments.

Responsibilities

• Lead downstream analytical workflows using HPLC and related techniques.
• Contribute to the purification and characterisation of large molecules.
• Mentor junior colleagues and ensure compliance with quality standards.

Skills

Experience with HPLC

Analytical Chemistry knowledge

Bioprocessing techniques

Communication skills

Problem-solving skills

Education

PhD in Analytical Chemistry or related field

Tools

HPLC

UPLC

Tangential flow filtration (TFF)

Job description

Senior Scientist – Downstream Analytics (Large Molecules)

Biotech | HPLC | Bioprocessing | Southampton | Up to £50,000 + Benefits

We’re partnering with an innovative scientific organisation to recruit a Senior Scientist with strong experience in downstream analytical processes, including HPLC and bioprocessing techniques, to join a high-performing team based in Southampton. This hands‑on role offers the chance to support the development of modified nucleic acids and peptides, drive analytical method development, and contribute to the advancement of large molecule therapeutics in a collaborative, fast‑paced environment.

About the Role

You’ll take the lead on analytical workflows for nucleic acids, peptides, and antibodies, ensuring high standards of quality, compliance, and scientific rigour. The role will include method development, instrument maintenance, and cross‑functional collaboration across R&D and production teams.

This position is ideal for a scientist who enjoys working across disciplines, mentoring junior colleagues, and staying at the forefront of analytical innovation.

Key Responsibilities

• Lead downstream analytical workflows using HPLC, UPLC, PAGE, flash chromatography, and related techniques.
• Contribute to the purification and characterisation of large molecules, such as peptides and antibodies.
• Support method development and continuous improvement in analytical approaches.
• Collaborate with chemistry and production teams to support small molecule and oligonucleotide preparation.
• Maintain, calibrate, and optimise analytical instrumentation in line with ISO and internal quality systems.
• Mentor and support Associate Scientists and Lab Technicians.
• Ensure accurate documentation and maintain data integrity across workflows.
• Promote and uphold Health, Safety, and Environmental (HSE) standards.
• Manage stock levels of analytical reagents and consumables.
• Stay up to date on emerging trends in bioprocessing and analytical technologies.

About You

We’re looking for a motivated and collaborative scientist with a solid grounding in downstream analytical techniques and a passion for quality science.

You’ll ideally have:

• A PhD (or equivalent experience) in Analytical Chemistry, Biochemistry, or a related field.
• Strong hands‑on experience in HPLC and bioprocessing within a biotechnology, pharmaceutical, or life sciences environment.
• Knowledge of purification and characterisation methods for peptides, antibodies, or similar large molecules.
• Experience with TFF or tangential flow filtration (advantageous).
• Familiarity with ISO or GMP‑regulated environments.
• Ability to lead technical projects and support team development.
• Strong communication and problem‑solving skills.
• A flexible, proactive mindset with strong attention to detail.

Salary & Benefits

• Salary: Up to £50,000 depending on experience
• Location: On‑site in Southampton
• Holidays: 25 days annual leave + 8 bank holidays
• Pension: 6% employer contribution
• Life Assurance: 4x salary
• Flexible working hours
• Long service awards and recognition scheme
• Employee Assistance Programme with 24/7 remote GP access
• Annual flu vaccinations
• Cycle to work scheme and gym discounts
• Discounts and savings platform
• Professional membership reimbursement
• Referral incentives
• Social events and volunteering days