Senior Liver Cell Scientist- Research Scientist

King's College Hospital NHS Foundation Trust; Greater London; On-site; GBP 35,000 - 45,000; Full time

Job summary

A major healthcare institution in Greater London is seeking a researcher to join their multidisciplinary team in advancing hepatocyte transplantation in children. The role involves investigating immunomodulatory effects of MSCs using various techniques including flow cytometry and ELISA. Candidates should possess a PhD in Cell Biology or Immunology and relevant experience in cell-based and immunoassays. The position supports the academic development of junior researchers and offers a dynamic research environment.

Qualifications

• Proven experience with cell-based assays, immunoassays, and flow cytometry in research.
• Experience in MSC biology or translational applications.

Responsibilities

• Conduct independent research on immunomodulatory effects of MSCs.
• Employ cellular and molecular techniques, including flow cytometry and ELISA.
• Collaborate with other researchers and clinical partners.
• Present findings at research meetings and contribute to publications.
• Support junior researchers and students.
• Participate in GMP-compliant cell isolation and processing.

Skills

Cell-based assays

Immunoassays (e.g. ELISA)

Flow cytometry

MSC biology

Translational applications

Education

PhD in Cell Biology/ Immunology or equivalent experience

Job description

Job overview

The post holder is a member of a multidisciplinary team developing the use of hepatocyte transplantation in children with liver-based metabolic disorders. They will be based at the Institute of Liver Studies laboratories within the Cheyne Wing at King's College Hospital.

The post holder shall work on a research project which aims to explore the immunomodulatory and regenerative potential of MSCs, with the goal of developing advanced therapy medicinal products (ATMPs) for clinical translation.

Main duties of the job

• Conduct independent research into the immunomodulatory effects and therapeutic mechanisms of MSCs in biliary atresia models.
• Employ a range of cellular and molecular techniques, including flow cytometry, ELISA, and advanced microscopy.
• Collaborate closely with other researchers within the Hepatocyte Biology and Transplantation Group and with clinical partners.
• Present work at weekly research meetings and contribute to publications, grant applications, and conference presentations.
• Support junior researchers and students, providing scientific advice and training where appropriate.
• Participate in GMP-compliant cell isolation and processing where required.
• Engage with the broader scientific and clinical community through lectures, seminars, and journal clubs.

General

• The post holder has a general duty of care for their own health, safety and wellbeing and that of work colleagues, visitors and patients within the hospital, in addition to any specific risk management or clinical governance accountabilities associated with this post.
• To observe the rules, policies, procedures and standards of King's College Hospital NHS Foundation Trust together with all relevant statutory and professional obligations.
• We want to be an organisation where everyone shares a commitment to delivering the very best care and feels like their contribution is valuable and valued.
• At King's we are a kind, respectful team:
  • Kind. We show compassion and understanding and bring a positive attitude to our work.
  • Respectful. We promote equality, are inclusive and honest, speaking up when needed.
  • Team. We support each other, communicate openly, and are reassuringly professional.
• To observe and maintain strict confidentiality of personal information relating to patients and staff.
• To be responsible, with management support, for their own personal development and to actively contribute to the development of colleagues.
• This job description is intended as a guide to the general scope of duties and is not intended to be definitive or restrictive. It is expected that some of the duties will change over time and this description will be subject to review in consultation with the post holder.
• All employees must hold an 'nhs.net' email account which will be the Trust's formal route for email communication.
• Everyone is responsible for promoting inclusion no matter their role or team. At King's, we want to create an environment where everyone feels valued, respected and welcomed.

Safe Guarding

• attending mandatory training on safeguarding children and adults
• familiarising themselves with the Trust's processes for reporting concerns
• reporting any safeguarding child or adult concerns appropriately

Infection Control Statement

The post holder has an important responsibility for and contribution to infection control and must be familiar with the infection control and hygiene procedures and requirements when in clinical areas.

The post holder has an important responsibility for and contribution to make to infection control and must be familiar with the infection control and hygiene requirements of this role.

These requirements are set out in the National Code of Practice on Infection Control and in local policies and procedures which will be made clear during your induction and subsequent refresher training. These standards must be strictly complied with at all times.

Person specification

Qualifications

Essential criteria

• PhD in Cell Biology/ Immunology or equivalent experience.
• Proven experience with cell-based assays, immunoassays (e.g. ELISA), and flow cytometry and cell therapy research, ideally with MSC biology or translational applications.

Desirable criteria

• in GMP-compliant cell isolation and processing where required

IMPORTANT

• Check your email account regularly as this is how we will communicate with you.
• If you delete the job from any of your accounts, you may be prevented from accessing further communications.
• To enquire about your application or inform us of any changes in your circumstances, please contact the named person on this advert.
• Please provide email addresses for referees where possible.
• Click here to see the range of benefits we offer.
• Please review the documentation on our recruitment microsite, particularly the Trust's criminal records checking policy.
• All staff have a responsibility for safeguarding children and vulnerable adults and for ensuring they are aware of the specific duties relating to their role.
• Please note that the closing date is given as a guide. On occasion, we might close a vacancy early due to a high number of applications being received. You are advised to submit your application as early as possible to avoid disappointment.