Scientist Protein Purification and Biochemistry

ZipRecruiter; Cambridge; On-site; GBP 30,000 - 40,000; Full time

Job summary

A biotech start-up in Cambridge is seeking a Scientist specializing in Protein Purification and Biochemistry. This 1-year fixed term contract role involves managing protein expression and purification to support the development of novel immunotherapies. Candidates should have a BSc in a relevant discipline and hands-on experience with purification techniques such as Protein A and affinity chromatography. Applicants must be entitled to work in the UK.

Qualifications

• A minimum of a BSc Degree in a related discipline.
• Hands-on experience with techniques like Protein A and affinity chromatography.
• Understanding of SPR techniques applied to therapeutic antibodies.

Responsibilities

• Manage and coordinate recombinant protein expression and purification.
• Develop innovative approaches for protein production challenges.
• Collaborate with cross-functional teams to meet project objectives.

Skills

Hands-on experience with protein purification techniques

Understanding of analytical techniques

Experience working with matrices such as cell lysates and human serum

Education

BSc Degree in Biochemistry, Molecular Biology, or related discipline

Job description

Overview

CK Group are recruiting for a Scientist – Protein Purification and Biochemistry to join a biotech start-up focused on developing novel immunotherapies. The role will be based at their site in Cambridge and is a 1 year Fixed Term Contract role, with Mon-Fri day time working hours.

Responsibilities

• Manage and coordinate recombinant protein expression and purification at CROs and/or in-house, ensuring protein quality and suitability for downstream assays.
• Developing innovative approaches to overcome complex protein production and purification challenges.
• Driving continuous improvement in protein delivery methodologies.
• Collaborating with cross-functional teams to support and deliver to key project objectives.
• Acting as a technical lead to establish science work plans with relevant outsourcing partners.
• Supporting the gap analysis and leading the initiative to identify new outsourcing partners to optimise delivery timelines and efficiencies.
• Work with CROs to ensure candidates meet therapeutic development criteria.

Your background

Essential:

• A minimum of a BSc Degree in Biochemistry, Molecular Biology, or related discipline
• Hands-on experience with protein purification techniques (Protein A, affinity chromatography, SEC)
• Experience working with matrices such as cell lysates and human serum
• Understanding of analytical techniques (SEC, SDS-PAGE, charge-based assays, mass spectrometry) applied to therapeutic proteins
• Understanding of SPR techniques applied to therapeutic antibodies
• Awareness of therapeutic antibody development considerations

Desirable:

• Experience coordinating protein expression and purification in CRO or in-house settings
• Experience with biochemical assays such as SPR and ELISA
• Familiarity with antibody optimization approaches
• Ability to run SPR experiments on therapeutic antibodies

Apply

It is essential all applicants hold entitlement to work in the UK. Please quote job reference 153 477 in all correspondence.