Research Scientist - Immune Reset

CK Group- Science, Clinical and Technical; Slough; On-site; GBP 100,000 - 125,000; Full time

Job summary

A global pharmaceutical company is seeking a Research Scientist - Immune Reset for a 12-month contract in Slough. Responsibilities include supporting therapeutic molecules through research and clinical development, performing in vitro assays, and maintaining compliance with HTA regulations. Candidates must have experience with immune cell assays and flow cytometry, alongside a strong background in analysis software. This role requires entitlement to work in the UK.

Qualifications

• Experience of performing functional immune cell assays including cytotoxicity and proliferation assays.
• Knowledge of assays to assess Fc mediated depletion mechanisms.
• Experience in isolation of primary immune cell subsets from whole blood.
• Proficiency in multi-parameter flow cytometry.

Responsibilities

• Support the progression of therapeutic molecules at all stages of research and clinical development.
• Perform translational in vitro assays for novel therapeutics.
• Develop and perform relevant functional assays for screening and target validation studies.
• Analyze and troubleshoot scientific data.
• Maintain compliance with procedures and HTA regulations.

Skills

Functional immune cell assays

Flow cytometry

Data analysis software proficiency (Flow Jo, GraphPad Prism, Excel, R)

Compliance with human tissue act guidelines

Job description

Overview

CK Group are recruiting for a Research Scientist - Immune Reset to join a global pharmaceutical company on a contract basis initially for 12 months.

Salary: £23-£28 per hour PAYE

Responsibilities

• Support the progression of therapeutic molecules at all stages of research and clinical development.
• Perform translational in vitro assays to evaluate novel therapeutics, investigate mechanisms of action and identify novel therapeutic axes.
• Develop and perform relevant functional assays for screening, mechanism of action and target validation studies as appropriate.
• Analyse and interrogate scientific data and demonstrate ability to troubleshoot technical issues.
• Maintain compliance to procedure by completing training modules and maintaining accurate experimental records.
• Comply with human tissue act (HTA) regulations, ensuring the relevant training is up-to-date and that HTA policies and procedures are read and understood.

Your Background

• Experience of performing functional immune cell assays including cytotoxicity assays, proliferation assays, mixed lymphocyte reactions and antigen recall assays.
• Knowledge of assays to assess mechanisms of Fc mediated depletion such as ADCC, ADCP or CDC.
• Experience in the isolation of primary immune cell subsets from whole blood using FACS and MACS.
• Experience in multi-parameter flow cytometry, including design of large antibody panels to provide deep profiling of immune cell subsets.
• Proficiency in relevant software packages for data analysis - e.g., Flow Jo, GraphPad Prism, Excel, and R.
• History of compliance with human tissue act guidelines for work with primary human cells/tissues.

Company

Our client is a is a global biopharmaceutical company focused on creating value for people living with severe diseases in immunology and neurology now and into the future.

Location

This role is based at our client's site in Slough.

Apply

For more information, or to apply for this Research Scientist - Immune Reset please contact the Key Accounts Team on (phone number removed) or email (url removed). Please quote reference (Apply online only).

It is essential that applicants hold entitlement to work in the UK.

Please note:This role may be subject to a satisfactory basic Disclosure and Barring Service (DBS) check.

INDKA