Research Associate Protein Sciences

Scorpion Therapeutics; England; On-site; GBP 30,000 - 45,000; Full time

Job summary

A biotechnology company in the UK seeks a skilled individual for an R&D role focused on antibody and protein purification. This position involves working with a small team, contributing to the design and operation of purification workflows, and executing experiments to support antibody discovery efforts. The ideal candidate has a Bachelor's degree in molecular biology or related field, with experience in protein purification and cell culture. Strong communication skills and the ability to work on multiple projects are essential.

Qualifications

• 1+ years of bench industry experience.
• Strong knowledge of protein purification and characterization.
• Ability to design and execute antibody discovery workflows.

Responsibilities

• Contribute to protein production and analytics workflow.
• Purify proteins and antibodies using FPLC systems.
• Assist in developing new assays for protein characterization.

Skills

Protein purification

Biophysical characterization techniques

Mammalian cell culture

Bacterial cell culture

Analytical methods for protein characterization

Education

Bachelor’s degree in molecular biology, biochemistry, or a related field

Tools

Akta FPLC systems

Biosensor assays

Job description

Role Summary

In this role you will be responsible for the design and day-to-day operation antibody and protein purification, characterization and protein analytics workflows at Invivyd. This position will work collaboratively with antibody discovery researchers and project managers. As part of a small research team, you will report to a PhD scientist and have the opportunity for scientific and professional mentorship and well as ownership of your research work. You will play a key technical role in the experimentation required to discover and advance candidate antibody molecules for development. The successful candidate will serve as a key member of the R&D team, supporting the up/down selection of antibody candidates throughout the therapeutic discovery and development process.

Responsibilities

• Contribute to Invivyd’s protein production and analytics workflow
• Demonstrates reliable technical skills in a focused number of methodological areas including various binding and biophysical characterization techniques including biosensor (Octet, Biacore) assays, thermal stability, and light scattering
• Purify proteins and antibodies using FPLC systems (Akta) and various from of chromatography
• Assist in developing new assays for protein characterization within the context of antibody discovery campaigns
• Support basic Antibody engineering efforts, including Fab and scFv preparation and purification
• Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
• Performs initial analysis of experimental data and interprets immediate experimental outcomes and/or conclusions within established protocols
• Participates in the planning and performance of experiments within standard procedures with minimal supervision
• Troubleshoots routine technical problems within standard procedures and performs regular quality control audits on instrumentation and associated outputs
• May be expected to present during internal research and development team meetings

Qualifications

• Bachelor’s degree in molecular biology, biochemistry, or a related field, and 1+ years of bench industry experience
• Experience in mammalian and bacterial cell culture with an emphasis on protein expression
• Strong knowledge and wet-lab experience performing protein purification and characterization using Akta FPLC systems, BLI (highly preferred), and functional assays
• Experience or understanding of various analytical methods for protein characterization and developability assessment of drug candidates is preferred
• Proactive team player and flexibility to work on multiple projects as the discovery programs evolve over time
• Ability to design and execute antibody discovery workflows and interpret in-process readouts
• Excellent verbal and written technical and non-technical communication skills