Principle Statistician Role

Barrington James Limited; Greater London; Hybrid; GBP 60,000 - 80,000; Full time

Job summary

A leading consultancy is seeking a Principal Statistician to lead evidence synthesis programs and provide statistical strategy on high-impact HTA projects. This role involves designing statistical plans, overseeing quality control, and mentoring junior statisticians. The ideal candidate will have a Master’s or PhD in a quantitative field, significant experience in evidence synthesis, and proficiency in R. The position offers a flexible working culture and exposure to diverse HTA-focused projects.

Benefits

Flexible working culture

Interaction with senior leadership

Broad exposure across therapeutic areas

Qualifications

• Significant experience leading evidence-synthesis statistical work.
• Strong track record in HTA-focused analyses.
• Experience leading or mentoring statisticians.

Responsibilities

• Designing statistical analysis plans for evidence-synthesis.
• Running analyses including meta-analysis and NMA.
• Overseeing quality control processes.

Skills

Evidence synthesis

Statistical analysis

Leadership

Communication of complex concepts

Proficiency in R

Education

Master’s degree or PhD in a quantitative discipline

Tools

R

Bayesian approaches

Job description

Principal Statistician – Evidence Synthesis & HTA

Location: Oxfordshire or London
Sector: HEOR / Evidence Synthesis / HTA
Type: Permanent, full-time

Our client is seeking a Principal Statistician to lead complex evidence‑synthesis programmes and guide statistical strategy across high‑impact HTA and market access projects. This role offers substantial influence, technical leadership, and the opportunity to shape methodologies within a collaborative, methodologically focused team.

The Role

As a Principal Statistician, you will own the design, delivery, and interpretation of statistical components across multiple evidence‑synthesis and HTA projects. You will partner closely with multidisciplinary teams while providing direction and mentorship for developing statisticians.

Key responsibilities include:

• Designing statistical analysis plans and feasibility assessments for advanced evidence‑synthesis challenges.

• Coding and running analyses including pairwise meta‑analysis, NMAs (including time‑varying survival models), MAIC/PAIC, and individual patient data analyses.

• Overseeing quality control processes to ensure methodological rigour and reproducibility.

• Communicating complex statistical results clearly to clients and cross‑functional teams.

• Leading contributions to proposals, pitch presentations, and development of internal methodologies, SOPs, and QC frameworks.

• Providing technical leadership, coaching, and mentorship to junior and mid‑level statisticians.

About You

You bring depth of experience in evidence synthesis and thrive in roles that blend analytical excellence, leadership, and intellectual ownership. You enjoy shaping projects, influencing decision‑making, and raising the statistical bar within a team.

Essential experience:

• Master’s degree or PhD in a quantitative discipline.

• Significant experience leading evidence‑synthesis statistical work (meta‑analysis, NMA, indirect comparisons).

• Proficiency in R, with familiarity in Bayesian approaches (e.g., BUGS).

• Strong track record in HTA‑focused analyses and interpreting results for health economic models and submissions.

• Experience leading or mentoring statisticians and influencing analytical approaches.

• Clear and confident communication of complex statistical concepts to diverse audiences.

Desirable:

• Experience with advanced NMA developments (e.g., ML-NMR).

• Experience delivering training or statistical learning initiatives.

• Consultancy experience managing multiple projects simultaneously.

What’s on Offer

You’ll join a supportive, engaging environment where quality, curiosity, and development are central. Expect:

• A flexible working culture with genuine autonomy.

• Regular interaction with senior leadership and the chance to shape internal methodologies.

• Broad exposure across therapeutic areas and diverse HTA‑focused projects.

• The influence and visibility expected of a true Principal‑level role.