Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability L[...]

The Francis Crick Institute; Greater London; On-site; GBP 100,000 - 125,000; Full time

Job summary

A leading biomedical research institute in Greater London is looking for a Postdoctoral Project Research Scientist. This role involves researching cancer evolution and genomic instability. The ideal candidate should possess a PhD and experience with cancer genomics data, along with proficiency in R or Python. This position offers a competitive salary, benefits, and opportunities for collaboration in a dynamic research environment.

Benefits

28 days of annual leave

Defined contribution pension scheme

24/7 GP consultation services

Discounted gym memberships

Childcare support allowance

Social events and team interaction spaces

Qualifications

• PhD in a relevant field.
• Previous experience with cancer genomics NGS data.
• Proven experience in high impact publications.

Responsibilities

• Investigate cell lineage in lung cancer initiation.
• Employ informatics techniques for tumor evolution analysis.
• Collaborate across teams and support PhD students.

Skills

Cancer genomics

Fluent in R

Fluent in Python

Collaboration with clinicians

Experience in evolutionary biology

Education

PhD

Tools

HPC environments

Job description

Salary for this Role: From £45,500 with benefits, subject to skills and experience.

Job Title:

Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Reports to:

Charles Swanton [C]

Closing Date:

31/Dec/2025 23.59 GMT

Job Description:

Job Title:

Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Details of the role:

Reporting to: Charles Swanton, Principal Investigator, Deputy Clinical Director

Contact term: This is a full-time 2 year position on Crick terms and conditions of employment.

Salary for this Role: From £45,500 with benefits, subject to skills and experience

Application Closing date: 31st of December 2025 at 23.59

About us

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world‑class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state‑of‑the‑art infrastructure, cutting‑edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high‑quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

We are looking for a creative and enthusiastic Postdoctoral Project Research Scientist to join the C Swanton Cancer Evolution and Genome Instability Laboratory.

This lab studies how cancers evolve in the body to spread and become resistant to therapy and discovers new ways to treat them more effectively. The research highlights that tumours consist of diverse groups of genetically related cancer cells, some of which adapt to resist treatments like chemotherapy, immunotherapy, radiotherapy, and targeted therapy. This resistance makes recurrent cancers more difficult to treat, particularly in diseases such as lung cancer.

The Project

As a PPRS you will investigate the role of cell lineage upon lung cancer initiation, both in homeostasis and in the context of challenge with non‑mutagenic carcinogens. You will seek to understand which cells within the lung are most susceptible to air pollutants and the routes they take to tumourigenesis. By identifying common pathways across different lineages, you will aspire to identify actionable targets suitable for therapeutic intervention to prevent the onset of cancer. Additionally you will contribute to research which is committed to advancing our understanding of the biology of lung tumour evolution.

You will need to have a creative approach to research with wet lab competencies, and encourage applicants with wet and dry lab skills to apply. As Postdocs may lead projects, collaborate across teams and partners, and support PhD students, it is essential yo have strong communication and collaboration skills.

What you will be doing

To be a successful PPRS for this role, you will need:

• To decipher evolutionary mechanisms during lung cancer initiation and progression using data from animal models.
• To employ novel informatics techniques based on evolutionary principles to the analysis of tumour subclonal evolution.
• To understand cancer biology and the relevant literature sufficiently to take own ideas forward as lead author on new projects.
• To work within the informatics team of the TRACERx and TRACERx EVO programs.
• To record all experiments and code in an accurate timely, clearly presented and reproduceable manner
• To contribute to the dissemination of scientific results by means of writing papers for publication and presentations.

Please click here to read about the lab

See the full job description here

About you

You will have:

• PhD*
• Previous experience with cancer genomics NGS data*
• Fluent in R or Python*
• Evidence of significant contribution to high impact publications*
• Experience with HPC environments
• Experience of collaboration with clinicians and wet lab scientists or work within a multi‑disciplinary environment
• Experience in evolutionary biology or cancer biology

*Minimum Criteria

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.

• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.

• We are collegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity and personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we’ll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post) please email: [e-mail]

Find out more about life at the Crick.

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well‑being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK

• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.

• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.

• Health & Well‑being:

• 24/7 GP consultation services.

• Occupational health services and mental health support programs.

• Eye care vouchers and discounted healthcare plans.

• Work-Life Balance:

• Back‑up care for dependents.

• Childcare support allowance.

• Annual leave purchase options.
• Crick Networks offering diverse groups’ support, community and inclusive social events.

• Perks:

• Discounted gym memberships, bike‑to‑work scheme, and shopping discounts.

• Subsidised on‑site restaurant and social spaces for team interaction.

Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed.

We reserve the right to withdraw this advert at any given time due to the number of applications received.