Medicinal Chemist

JR United Kingdom; Cambridge; On-site; GBP 45,000 - 70,000; Full time

Job summary

A biotech company in Cambridge is seeking a medicinal chemist to drive the development of novel therapeutics. The role involves designing and synthesizing compounds, managing CRO relationships, and requires a PhD in synthetic organic chemistry along with significant industry experience. Ideal candidates will have a strong background in drug discovery, particularly in oncology, and skills in data management and project oversight.

Qualifications

• 5+ years of industry experience within pharma/biotech.
• Experience with drug discovery programmes in oncology.
• Ability to integrate disease biology, ADME/PK and toxicology data.

Responsibilities

• Design and synthesise novel small molecules.
• Monitor and interpret biological and physicochemical property data.
• Manage multiple CRO relationships and provide guidance.
• Draft and maintain patent applications and scientific publications.

Skills

Organic chemistry

Medicinal chemistry

Drug discovery

Data management

Project management

Education

PhD in synthetic organic chemistry

Tools

Commercial data management systems

In silico tools

Job description

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Genome Therapeutics Ltd (GTx) is seeking a medicinal chemist with experience in pre-clinical drug discovery to drive the development of novel therapeutics that target G-quadruplex structures. The ideal candidate will manage outsourced drug discovery activities and play a key role in the design and synthesis of lead compounds, applying a comprehensive understanding of medicinal chemistry principles across internal programmes from hit-to-lead through to candidate nomination.

GTx is a fast paced multidisciplinary company, offering training and experience in genomics, computational biology, drug discovery and clinical studies.

Location: This is an on-site position based at the GTx labs in Cambridge UK.

Key Responsibilities

• Leverage expertise in organic and medicinal chemistry to design and synthesise novel small molecules across multiple programmes and chemotypes
• Monitor and interpret biological, ADME/PK, and physicochemical property data to propose and execute innovative strategies for improving key drug attributes
• Manage multiple CRO relationships, providing synthetic and medicinal chemistry expertise and guidance, and driving productivity and deliverables
• Provide regular updates on project results both internally and externally
• Effective written communication, including responsibility for drafting and maintaining patent applications and scientific publications
• Meticulous record-keeping and strong data organisation using commercial data management systems and electronic notebooks
• PhD in synthetic organic chemistry with >5 years industry experience within pharma/biotech
• Exposure to medicinal chemistry programmes from hit identification through to candidate nomination
• Understanding of the multi-parameter optimisation process and ability to integrate disease biology, ADME/PK and toxicology data to solve complex drug discovery problems.
• Management of outsourced drug discovery projects
• Prior experience of drug discovery programmes in the field of oncology
• Knowledge of in silico tools to aid drug design