Clinical Pharmacologist

Mantell Associates; United Kingdom; On-site; GBP 60,000 - 80,000; Full time

Job summary

A leading biotech organization in the United Kingdom is seeking a Clinical Pharmacologist to lead the pharmacology strategy for AI-driven drug programs. The ideal candidate will possess an advanced degree in Clinical Pharmacology and demonstrate expertise in PK/PD modelling and quantitative analysis. Responsibilities include collaborating with multi-disciplinary teams and providing scientific leadership for regulatory submissions. This role offers a unique opportunity to influence drug development strategies and requires proven communication skills.

Qualifications

• Advanced degree in Clinical Pharmacology or related discipline.
• Demonstrated expertise in clinical pharmacology within biotech or pharma.
• Strong experience in PK/PD modelling and quantitative analysis.

Responsibilities

• Lead clinical pharmacology strategy for programs.
• Collaborate with cross-functional teams to integrate insights.
• Provide scientific leadership on regulatory submissions.

Skills

Clinical pharmacology

PK/PD modelling

Quantitative analysis

AI/ML applications

Excellent communication

Education

Advanced degree (PhD, PharmD or equivalent)

Tools

Physiologically-based pharmacokinetics (PBPK)

Job description

Mantell Associates is partnered with a fast-growing AI-centric biotech organisation, who is searching for a highly motivated and experienced Clinical Pharmacologist to lead translational science initiatives and drive quantitative decision‑making across our preclinical and early clinical programs.

Clinical Pharmacologist - Responsibilities:

• Lead clinical pharmacology strategy for AI‑driven small molecule and biologic programs, including dose prediction, modelling, simulation, and translational biomarkers
• Design and interpret PK/PD studies to inform candidate selection and optimisation across discovery and early development
• Collaborate with cross‑functional teams (AI/ML scientists, medicinal chemists, toxicologists, clinicians) to integrate clinical pharmacology insights into project decisions
• Develop innovative approaches to leverage AI platforms for predictive pharmacology and optimise clinical trial design
• Provide scientific leadership on regulatory submissions and interactions related to pharmacokinetics, pharmacodynamics and dosing rationale
• Apply quantitative systems pharmacology (QSP) and population modelling to support patient stratification and dose selection
• Mentor and guide junior scientific staff within the translational science function

Clinical Pharmacologist - Requirements:

• Advanced degree (PhD, PharmD or equivalent) in Clinical Pharmacology, Pharmacokinetics, Pharmacology or related discipline
• Demonstrated expertise in clinical pharmacology within biotech, pharma, or translational research
• Strong experience in PK/PD modelling, physiologically‑based pharmacokinetics (PBPK), population PK, and quantitative analysis
• Familiarity with AI/ML applications to drug discovery or clinical trial data is highly desirable
• Excellent communicator with ability to articulate complex scientific concepts to multidisciplinary audiences
• Proven track record of delivering translational outcomes that advance drug candidates toward clinical success
• Based in the UK (or eligible to work in the UK), with flexibility for occasional travel

Mantell Associates is a specialist Pharmaceutical and Life Science headhunting firm. For more information on this opportunity, contact us at [phone].