Cell Culture Scientist

Lonza; Cambridge; On-site; GBP 30,000 - 50,000; Full time

Job summary

A global life sciences leader in Cambridge is seeking a Scientist for Cell Expression & Engineering. The role specializes in developing mammalian expression hosts and optimizing cell line development processes. Candidates should possess a BSc/MSc in Life Sciences and have hands-on experience in cell culture and bioreactor operations. Innovative thinkers with problem-solving skills are encouraged to apply. This role offers a unique opportunity to impact bio-science positively.

Qualifications

• BSc/MSc Degree in Life Sciences, Molecular Biology, or related field.
• Practical experience within R&D in industrial or academic settings.
• Hands-on experience in mammalian cell culture, stable transfections, and bioreactor operations.

Responsibilities

• Contribute to the delivery of new CHO-based mammalian expression hosts.
• Culture mammalian cell lines and perform analytical procedures.
• Plan and execute experiments using the Ambr15 automated bioreactor platform.

Skills

Analytical skills

Problem-solving skills

Mammalian cell culture

Experience with Ambr15

Experience with Beacon

Education

BSc/MSc Degree in Life Sciences

Tools

Automated bioreactor platforms

Job description

Overview

Scientist - Cell Expression & Engineering

United Kingdom, Cambridge

Lonza is a global leader in life sciences operating across three continents. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. We let our people own their careers. Their ideas, big and small, genuinely improve the world. That’s the kind of work we want to be part of.

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. We offer the satisfaction that comes with improving lives all around the world and making a meaningful difference.

Responsibilities

• Contribute to the delivery of new CHO-based mammalian expression hosts and vector systems for the expression of complex therapeutic proteins
• Explore innovative ideas to optimise the cell line development (CLD) process including the use of automation equipments & novel technologies
• Culture mammalian cell lines in flasks and small-scale bioreactors and perform analytical procedures as required by the project
• Plan, execute, and monitor experiments using the Ambr15 automated bioreactor platform
• Troubleshoot technical issues with the Ambr15 system and liaise with vendors/technical support as needed
• Collate, analyse, evaluate and sign-off data to produce good quality information and traceable records under the direction of the project lead
• Support the development of study plans & other relevant documents
• Present results in written and oral reports
• Actively keep abreast of relevant academic literature (e.g., in the field of cell engineering and expression technologies)
• Contribute ideas and opinions to scientific discussions to aid the development of new technologies
• Working as a team player and working with a high degree of flexibility

Qualifications

• BSc/MSc Degree in Life Sciences, Molecular Biology, or a related field
• Practical experience within R&D in industrial or academic settings
• Hands-on experience in mammalian cell culture, stable transfections, single cell isolation and bioreactor operations (experience with Beacon and Ambr15 is highly desirable)
• Strong analytical and problem-solving skills, with the ability to manage multiple experiments in parallel
• Familiarity with implementation/development of automation for cell line screening & CLD process optimisation
• A proactive attitude to working and solving challenging problems

Approximate ideal subdivision

• Planning experiments/work and writing electronic lab notebook up (10%)
• Practical - Molecular biology and/or cell culture (80%)
• Lab Maintenance (e.g. prep of T/C hoods) (5%)
• Overhead work (time sheets/training departmental meetings etc.) (5%)