Master Thesis - Development of ligand conjugated lipid nanoparticles for targeted T cell delive[...]

Helmholtz Munich; Oberschleißheim; Vor Ort; EUR 40.000 - 60.000; Vollzeit

Zusammenfassung

A leading research institute in Germany is offering a Master's thesis project for a motivated student. You will work on lipid nanoparticles to enhance cell specificity, conducting lab work involving optimization, characterization, and functionality assessment of nanoparticles. Ideal for students enrolled in a Master's program with a background in biochemistry. The role offers comprehensive training and development opportunities as well as a flexible working environment.

Leistungen

Comprehensive in-house training

State-of-the-art scientific resources

30 days annual leave

Flexible working hours

Support with relocation

Qualifikationen

• Basic biochemistry knowledge and experience with laboratory work.
• Theoretical knowledge about nanoparticles and nucleic acid delivery.
• Experience with conjugation techniques and lipid nanoparticles is a plus.

Aufgaben

• Optimize targeting ligand conjugation to nanoparticle surface.
• Characterize nanoparticles for efficiency and specificity.
• Assess in vitro functionality of nanoparticles.

Kenntnisse

Biochemistry knowledge

Laboratory work experience

Conjugation techniques

Cell culture experience

Ausbildung

Enrolled in a Master's program

Jobbeschreibung

Overview

At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives.

The Institute for Intelligent Biotechnologies (iBIO) develops and implements tools to analyze biological samples' 3D structure and molecular identity. At iBIO, we bring together cutting-edge science from biology, chemistry, engineering, and computer applications. Our overarching aim is to obtain a holistic view of interconnected biological systems in health and disease. We develop clearing technologies for cellular-level imaging and deep learning algorithms (AI) to analyze large imaging and molecular data in a robust and unbiased way. Worldwide media coverage has highlighted our research. You can find out more about us here.

We are offering an exciting Master\'s thesis project for a motivated student (f/m/x). You will prepare lipid nanoparticles carrying targeting ligands for enhanced cell specificity and work with lipid nanoparticles carrying targeting ligands for enhanced cell specificity.

Responsibilities

• Optimization of the targeting ligand conjugation to nanoparticle surface (conjugation chemistry parameters, purification methods)
• Characterization of the nanoparticles (DLS, zeta potential, encapsulation efficiency, attachment efficiency)
• In vitro functionality assessment (cytotoxicity, cellular uptake, delivery and expression efficiency, cell specificity)

Your profile / Qualifications

• Enrolled in a Master's program
• Basic biochemistry knowledge and experience with laboratory work
• Theoretical knowledge about nanoparticles and nucleic acid delivery
• Experience with conjugation techniques, lipid nanoparticles, and cell culture is a plus
• Structured work style and the ability to work in a team are required

This position has a fixed term, depending on the requirements of your study program.

Application

Interested in applying? If you have any questions, feel free to contact Stefanie Reitinger, [e-mail], who will be happy to help. Our recruiting is decentralized — your application will be reviewed directly by the specialist department in which you could work in the future. More information about our application process

Please send your application only via our online application tool and with the following documents:

• CV
• Cover letter
• Degrees/Diplomas/Certificates

If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

Benefits

• Personal Development: Comprehensive in-house training and development opportunities
• Scientific Resources: State-of-the-art infrastructure and Core Facilities
• Recreation: 30 days annual leave, flexi days, plus public holidays
• International Staff Service: Support with the relocation and integration process in Germany
• Health Promotion: Sports, company doctor, mental health initiatives
• Work-Life-Balance: Flexible working hours and flexi-time models