Senior Global Project Manager – Immunology, Metabolic, and Oncology (Sponsor-Dedicated, Hybrid [...]

Syneos Health, Inc.; Toronto; Hybrid; CAD 100,000 - 130,000; Full time

Job summary

A leading biopharmaceutical solutions organization is seeking a Senior Global Project Manager to oversee clinical trials in Immunology, Metabolic, and Oncology. This pivotal role requires extensive leadership across global Phase II and III trials, focusing on operational oversight, strategic contributions, and team alignment. The position is hybrid, demanding 50% onsite collaboration in Burlington, Ontario, and emphasizes strong communication and project management skills. Join an agile team dedicated to accelerating therapies that change lives.

Benefits

Career development and progression

Supportive and engaged management

Recognition and rewards program

Qualifications

• Proven experience providing global leadership across Phase II & III clinical trials.
• Therapeutic area experience in Immunology, Metabolic, or Oncology.
• Deep understanding of global clinical trial planning and execution.

Responsibilities

• Lead global planning activities and operational feasibility assessments.
• Maintain high-level oversight of worldwide trial operations.
• Provide global leadership through data cleaning and closeout activities.

Skills

Global leadership

Project management excellence

Strategic mindset

High-impact communication

Collaboration & influence

Education

Bachelor’s degree (4-year undergraduate degree)

Job description

Senior Global Project Manager – Immunology, Metabolic, and Oncology (Sponsor-Dedicated, Hybrid – Burlington, Ontario, Canada, 50% Onsite)

Updated: December 3, 2025
Location: Toronto, ON, Canada
Job ID: 25102846

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities.

Our Clinical Development model brings the customer and the patient to the center of everything that we do. We are continuously looking for ways to simplify and streamline our work to not only make Syneos Health easier to work with, but to make us easier to work for.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies, because we are passionate to change lives.

Discover what our 29,000 employees, across 110 countries already know:

WORK HERE MATTERS EVERYWHERE

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to our Total Self culture – where you can authentically be yourself. Our Total Self culture is what unites us globally, and we are dedicated to taking care of our people.
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because when we bring together diversity of thoughts, backgrounds, cultures, and perspectives – we’re able to create a place where everyone feels like they belong.

Senior Global Project Manager – Immunology, Metabolic, and Oncology

(Sponsor-Dedicated, Hybrid – Burlington, Ontario, Canada, 50% Onsite)

About the Role:

Within this sponsor, the Clinical Trial Leader (CTL) serves at the Senior Project Manager level and plays a pivotal leadership role within the Clinical Delivery Team. This position provides strategic global oversight, driving alignment, direction, and accountability across Phase II and III clinical trials conducted worldwide. The CTL ensures precise planning, efficient execution, and high‑quality delivery of trials that bring speed and value to patients and investigative sites.

This role is hybrid, requiring approximately 50% onsite presence in Burlington, Ontario. Time in the office is highly collaborative and energizing — you’ll work alongside scientists, operational leaders, and cross‑functional partners who depend on your leadership to keep global teams aligned. The onsite culture emphasizes real‑time problem solving, strong relationships, and a shared commitment to operational excellence. If you enjoy being a visible leader who influences teams across continents, this environment is a true advantage.

What You Will Do:

Global Trial Preparation

• Lead global planning activities and operational feasibility assessments, ensuring timelines and strategies are realistic and globally aligned.
• Strengthen cross‑functional cohesion by working onsite with colleagues in Statistics, Data Management, Medical Writing, Site Monitoring, Quality, and Regulatory.
• Guide country allocation and feasibility processes, helping shape global site strategies with operational insight.
• Develop robust global engagement, recruitment, and risk mitigation plans informed by patient, site, and regional feedback.
• Lead vendor outsourcing strategy—identification, evaluation, and scope‑of‑work development—ensuring global operational readiness.
• Bring teams together onsite to harmonize trial processes across clinical quality, safety, investigational product management, and financial planning.
• Prepare or support responses to regulatory and ethics authorities across regions.
• Ensure global teams are trained, aligned, and equipped for execution.

Global Trial Conduct

• Maintain high‑level oversight of worldwide trial operations, ensuring compliance with GCP, SOPs, and diverse regional regulations.
• Monitor global patient recruitment, risks, timelines, and budgets, driving issue resolution through clear leadership.
• Direct documentation changes, study amendments, and retraining across all regions and functions.
• Provide strong oversight of global vendors, central labs, and external partners, ensuring consistent performance.
• Serve as the connective tissue across global clinical delivery, fostering open communication and unity of purpose.
• Coordinate biomarker, genomic, and sub‑study activities for applicable early‑phase trials, often requiring cross‑regional alignment.

Trial Closeout & Reporting

• Provide global leadership through data cleaning, database lock, and closeout activities.
• Support CTR development and ensure timely global registry disclosure.
• Ensure completeness and accuracy of the Trial Master File (TMF) across all participating regions.
• Support scientific publications and global communication of study outcomes.

Strategic Contributions

• Partner with portfolio leaders to provide operational and scientific insight that shapes global study strategy.
• Elevate risks, bottlenecks, and insights to the Evidence Team to drive swift, coordinated solutions.
• Lead or contribute to global feasibility assessments that influence trial design, operational models, and regional planning.

What You Will Bring:

Required

• Bachelor’s degree (4-year undergraduate degree).
• Proven experience providing global leadership across Phase II & III clinical trials.
• Therapeutic area experience in Immunology, Metabolic, or Oncology.
• Deep understanding of global clinical trial planning, execution, and regulatory landscapes.
• Exceptional leadership, communication, and stakeholder management skills across complex, matrixed, multicultural environments.
• Ability to lead through influence, anticipate global challenges, and ensure patient‑focused outcomes.

Core Competencies

• Global Leadership: Confidently guide teams across regions, cultures, and functions; set vision, instill accountability, and shape high‑performing global execution.
• Strategic Mindset: Think several steps ahead, anticipate challenges, and align global strategies with portfolio needs.
• Project Management Excellence: Expert in global timelines, risk mitigation, cross‑functional coordination, issue escalation, and solution delivery.
• Collaboration & Influence: Build trust across continents; unify teams through clear direction and inspiring presence onsite.
• High‑Impact Communication: Transparent, diplomatic, and culturally attuned communicator who elevates team performance.

Why Join This Team:

This is not a traditional project management role — it is a chance to be at the center of global clinical delivery. As a Senior Global Project Manager / Clinical Trial Leader, you will be a visible, influential leader driving the success of trials that span continents. The hybrid model gives you the best of both worlds: meaningful onsite collaboration that strengthens team cohesion, paired with the flexibility of remote work.

You will shape strategy, drive execution, and help deliver therapies that change lives. Your leadership will connect people, processes, and science — ensuring trials advance efficiently, ethically, and with global impact.

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever‑changing environment. Learn more about Syneos Health.

http://www.syneoshealth.com

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.

Summary

The Clinical Trial Leader (CTL) is a key member of Clinical Delivery Team nominated to a specific trial within the Evidence Network. CTLs are accountable for the set‑up, execution and delivery of their assigned trial(s) and contribute to delivery of pipeline through accurate planning and efficient execution of trials that bring speed & value to participating subjects and sites.The CTL provides leadership and direction to the trial team (core and extended team members) and is accountable for the overall success and delivery of their assigned clinical trial according to defined milestones and key performance indicators. They are responsible for steering and directing clinical trial activities, including patient and site engagement activities, direct communication and interaction with multiple internal and external stakeholders (e.g. investigative sites) and team members on a global, multi‑country or regional basis.The CTL is responsible for managing the planning, implementation, and tracking of the clinical trial process as well as risk mitigation. The CTL serves as a proactive member of the clinical delivery team, liaising closely with the Clinical Trial Managers (“CTM”) on all study‑related issues. As leader of the Trial Team, the CTL communicates trial status to stakeholders, escalating issues as appropriate.

Discover what our more than 29,000 employees already know: work here matters everywhere. We work hard,and smart, all in the name of getting much‑needed therapies to thosewho need them most. A career with Syneos Health means your everyday work improvespatients’ lives around the world. Selecting us as an employer secures a career inwhich you’re guaranteed to:

Syneos Health ® (Nasdaq:SYNH) is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities. Together we share insights, use the latest technologies and apply advanced business practices to speed our customers’ delivery of important therapies to patients. We support a diverse, equitable and inclusive culture.