Scientist, Laboratory of Precision Disease Therapeutics (GIS)

Agency for Science, Technology and Research (A*STAR); Singapore; On-site; SGD 60,000 - 80,000; Full time

Job summary

A leading research organization in Singapore seeks a PhD-trained scientist specializing in early drug discovery for metabolic diseases. The role requires extensive experience in RNA therapeutics, managing CRO collaborations, and analytical problem-solving skills. Candidates should possess a PhD and be proficient in data management using software like SPSS, R, or Python. This position offers a competitive salary and benefits package in a vibrant scientific community at the Genome Institute of Singapore.

Benefits

Competitive salary

Complete benefits package

High standard of living in Singapore

Qualifications

• Experience in data collection, management, and analysis.
• Proficient in conducting literature reviews.
• Excellent organizational and time management skills.

Responsibilities

• Lead and execute discovery projects on metabolic diseases.
• Manage CRO collaborations for high-quality data delivery.
• Collaborate with teams in medicinal chemistry and pharmacology.

Skills

Drug Discovery Expertise

RNA Therapeutics

Target Validation & Disease Biology

Analytical & Critical Thinking

In Vitro & In Vivo Models

Scientific Communication

Education

PhD in a relevant field (e.g., biology, biochemistry)

Tools

SPSS

R

Python

Job description

We seek a PhD-trained scientist with expertise in early drug discovery for metabolic diseases, with several years of experience (ASO/siRNA therapeutic modality is preferred), target validation, and MASH research. Demonstrated ability to lead and execute discovery projects in both in-house and CRO-based settings, ensuring high-quality data delivery and efficient project progression.

Core Competencies:

• Drug Discovery Expertise: Strong track record in early discovery, from target identification to validation, hit-to-lead and preclinical assessment.
• RNA Therapeutics (preferred): Hands-on expertise with ASO and siRNA platforms, including design, in vitro/in vivo validation, and optimization for metabolic disease applications.
• Target Validation & Disease Biology: Experienced in establishing mechanistic links between targets and disease biology, with emphasis on MASH and metabolic disorders.
• Working with CROs: Effective in managing CRO collaborations, ensuring study design quality, data integrity, and timely execution of in vitro/in vivo experiments.
• Analytical & Critical Thinking: Skilled in data interpretation, decision-making, and problem-solving, enabling robust conclusions and informed go/no-go project decisions.
• In Vitro & In Vivo Models: Proficient in cellular assays, screening compounds, critical assay flow scheme design, rodent disease models, and translational PD marker strategies relevant to disease.
• Cross-functional Collaboration: Experience working closely with medicinal chemistry, pharmacology, and safety and toxicology teams to advance therapeutic candidates.
• Scientific Communication: Strong publication record, conference presentations, and ability to translate complex science for diverse stakeholders.

You will need:

• PhD degree in a relevant field (e.g., biology, biochemistry etc.).
• Experience in data collection, management, and analysis using software such as SPSS, R, or Python.
• Proficient in conducting literature reviews and synthesizing research findings.
• Excellent organizational and time management skills, with the ability to work on multiple projects simultaneously.
• Effective written and verbal communication skills, including the ability to present research findings.
• Attention to detail and commitment to maintaining data accuracy and confidentiality.

Interested applicants are invited to send:

• Resume
• Contacts of minimum two referees
• A brief statement explaining research achievements (1 to 2 pages)

We regret that only shortlisted candidates will be notified.

About the Genome Institute of Singapore

The Genome Institute of Singapore (GIS, A*STAR) is the national flagship program for genomic science in Singapore. GIS is located within the Biopolis, the biomedical research hub of Singapore which houses, in close proximity, research institutes under the Agency of Science, Technology and Research (A*STAR), biotech startups and international pharmaceutical corporations. The applicant would have the opportunity to interact with scientists, informaticians, clinicians, engineers and other professionals from all over the world in a vibrant, intellectually stimulating and scientifically curious setting. You will be part of a vibrant scientific community where you will have the opportunity to share your ideas and demonstrate your skills and passion for scientific research. You can find out more about the Genome Institute of Singapore online: http://www.gis.a-star.edu.sg

The Genome Institute of Singapore offers a competitive salary and a complete benefits package that ensures a very high living standard in one of the most modern cities in the world.

Why Singapore?

Singapore is a city-state with one of the highest standards of living in the world seeking to become an international hub for the biomedical sciences. Singapore is a vibrant, tropical city, with rich Asian heritage and modern style of living, an ideal gateway to explore Asia, providing a unique experience and an excellent quality of life.

Contact and further information

More information about the Prof Ng Huck Hui’s lab including recent publications can be found online: https://www.a-star.edu.sg/gis/our-people/