Bioinformatics Scientist, Assay Design and Pipelines

ThermoFisher Scientific; Singapore; On-site; SGD 60,000 - 80,000; Full time

Job summary

A leading biotechnology company in Singapore seeks a skilled Bioinformatics Scientist to develop high-quality assays for qPCR and dPCR. You'll leverage your expertise in genomics to design assays, analyze genomic data, and optimize bioinformatics pipelines. Candidates should hold a PhD or Master's in a related field and possess strong programming skills in Python and R. Collaboration across teams is vital for success. The role offers a dynamic environment focused on innovative solutions in biotechnology.

Qualifications

• PhD or Master’s degree in Bioinformatics or related fields with 2+ years of experience.
• Strong genomics and molecular biology domain knowledge.
• Advanced Python and proficient R programming.

Responsibilities

• Design and optimize qPCR assays for multiple applications.
• Analyze genomic and sequence data for assay development.
• Maintain bioinformatics pipelines for assay development.

Skills

Strong programming for scripting (Python)

Analytical and problem-solving skills

Effective cross-functional collaboration

Strong domain knowledge in genomics

Education

PhD or Master’s degree in Bioinformatics or related fields

Tools

IGV

BLAST

BWA

Nextflow

Snakemake

Job description

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Office

Job Description

Position Summary

We are seeking a skilled and motivated Bioinformatics Scientist to join our team, specializing in assay and content development for qPCR, dPCR, and CE technologies. The role focuses on delivering high-quality assays on schedule and contributing to the development and maintenance of computational pipelines, databases, and infrastructure to scale assay development. This position requires strong domain knowledge of genomics, PCR-based methods, and proficiency in bioinformatics pipeline development. You will convert biological questions into assay strategies and assign robust primer/probe sets. You will streamline workflows and optimize code for efficiency and scalability. Collaboration with other bioinformatics scientists, product management, and customer support colleagues is essential.

Primary Responsibilities

• Design, develop, and optimize qPCR assays for various applications, including gene expression, genotyping, copy number analysis, and pathogen detection.
• Analyze and interpret complex genomic and sequence data to support target selection and assay development.
• Prepare and present scientific reports and presentations to communicate findings and progress.
• Develop, maintain, and optimize bioinformatics pipelines and workflow automation for large-scale assay development.
• Maintain version-controlled repositories, documentation, and reproducibility across computational workflows.
• Participate in the publication or productization of developed algorithms, pipelines, or tools.

Required Qualifications

• PhD or Master’s degree in Bioinformatics, Computational Biology, Molecular Biology, Bioinformatics, or related fields. Preferred with 2+ years of relevant experience.
• Strong genomics & molecular biology domain knowledge in at least one of the domains in plant, mammalian, microbial, and oncology systems.
• Bioinformatics stack: IGV, BLAST, BWA/other aligners; major databases (GenBank, Ensembl); experience across genomics, and quantitative data with strong analytical, problem-solving skills.
• Strong programming for scripting: advanced Python and proficient R, with additional experience in C/C++/Java/Perl/Python/JavaScript/ReactJS; solid debugging.
• Teaming & execution: excellent communication; effective cross-functional collaboration; able to work independently and manage multiple projects concurrently.

Preferred Qualifications

• Familiarity with machine learning or LLM-based methods or statistical methods for biological analysis.
• Experience with other assay development platforms, such as NGS, microarrays, etc.
• Familiarity with workflow orchestration frameworks (Nextflow, Snakemake, Latch) or cloud computing and high performance computing environments.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.