Research Associate in Advanced Cryo-Imaging

The Rosalind Franklin Institute; East Hagbourne; On-site; GBP 30,000 - 40,000; Full time

Job summary

A leading research institution in East Hagbourne is looking for a Research Associate in Advanced Cryo-Imaging to work on a maternity cover project for 12 months. The successful candidate will utilize advanced imaging techniques to unravel the mechanisms of HIV maturation in collaboration with Kings College. This role offers the opportunity to develop scientific independence and leadership skills while contributing to innovative research in molecular biology and virology.

Qualifications

• Scientific knowledge in cryogenic correlative imaging and HIV research is crucial.
• Ability to work collaboratively on advanced imaging and high-resolution structural analysis.

Responsibilities

• Exploit advanced cryogenic correlative imaging to study HIV maturation.
• Combine FLIM/FRET measurements with cryo-electron tomography for structural analysis.
• Push correlative techniques into cells or tissues for detailed insights.

Job description

Research Associate in Advanced Cryo-Imaging (Maternity Cover 12 Months)

As a Research Associate at the Franklin, you will bring scientific knowledge and skills to deliver a specific research project and/or you will bring independent, creative science, or specific skills to a team delivering a project or program. Through this work, you will build scientific independence, develop new science and leadership skills, and establish a growing reputation externally.

The successful candidate will exploit advanced cryogenic correlative imaging approaches to dissect the molecular, structural, and biophysical mechanisms governing HIV maturation and early entry. In collaboration with the group of Sergi Padilla at Kings College, you will combine time‑resolved FLIM/FRET measurements employing custom‑engineered biosensors with cryo‑electron tomography and high‑resolution structural analysis to resolve dynamic conformational and assembly processes during viral maturation, thereby delivering new mechanistic insights into HIV infectivity. The direction of the project will be to push this nascent correlative technique into the cell, potentially into tissues, to enable lifetime‑based correlation of features within the cell.

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