Job offer Postdoctoral Research Associate, School of Cardiovascular and Metabolic Medicine & Sc[...]

King's College London; Camden Town; On-site; GBP 35,000 - 45,000; Full time

Job summary

A leading university in the UK is seeking a postdoctoral scientist to develop gene editing technologies for cardiovascular diseases. The role involves conducting research using CRISPR/Cas9 and Prime Editing techniques, working with primary cardiomyocytes, and publishing in academic journals. Candidates should possess a PhD and expertise in molecular and cellular biology. This position offers a vibrant research environment and opportunities for international collaboration.

Qualifications

• PhD and/or MD with expertise in molecular and cellular biology and prior experience in gene editing.
• Strong expertise in cellular and molecular biology.
• Past experience in AAV vector-related work.
• Self-motivated with the ability to work independently.

Responsibilities

• Conduct research to develop gene editing technologies for cardiovascular diseases.
• Work with primary cardiomyocytes and human myocardial slices.
• Write and publish results in high-impact journals.
• Present findings at international conferences.

Skills

Molecular biology expertise

Gene editing experience

Cellular biology expertise

Self-motivated

Education

PhD and/or MD

Job description

Overview

Applications are invited for a talented and enthusiastic postdoctoral scientist to join Prof Mauro Giacca's laboratory at the School of Cardiovascular and Metabolic Medicine & Sciences at King's College London. The postholder will be part of a vibrant multi-disciplinary research group operating across different research themes in cardiac biology, with the aim to develop technologies for gene editing of cardiovascular inherited conditions. The post-holder will develop CRISPR/Cas9- and Prime Editing-based methods for correcting DNA mutations leading to cardiomyopathy. Work will be performed in primary cardiomyocytes from human iPS cells, human myocardial slices from patients and humanised mouse models with the same mutations as patients, all of which are currently available in the laboratory. The post is based within the School of Cardiovascular and Metabolic Medicine & Sciences at the James Black Centre (King's Denmark Hill campus) as part of the Kings College London BHF Centre of Research Excellence and the MRC/BHF Centre for Advanced Cardiac Therapeutics (REACT). The School and these Centres provide an outstanding, highly multidisciplinary environment with state-of-the-art equipment, facilities and technical support for both laboratory work and animal studies.

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's. As part of this commitment to equality, diversity and inclusion and through this appointment process, it is our aim to develop candidate pools that include applicants from all backgrounds and communities.

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Responsibilities

The post holder will conduct research to develop gene editing technologies for cardiovascular diseases, with a focus on CRISPR/Cas9- and Prime Editing-based approaches. This includes work with primary cardiomyocytes derived from human iPS cells, human myocardial slices from patients, and humanised mouse models carrying patient mutations. The role includes writing and publishing results in high-impact, peer-reviewed journals and presenting findings at international conferences.

Qualifications

• PhD and/or MD with expertise in molecular and cellular biology and prior experience in gene editing.
• Strong expertise in cellular and molecular biology.
• Past experience in AAV vector-related work.
• Self-motivated with the ability to work independently.

Desirable criteria

• Experience in animal models of cardiovascular disease.
• Experience in tissue and organ handling and processing, including histological analysis.
• Knowledge in cardiovascular medicine.

About the School

The School of Cardiovascular and Metabolic Medicine & Sciences (SCMMS) is one of six schools in the Faculty of Life Sciences & Medicine (FoLSM) at Kings College London. The School drives translation of world-leading basic science into advances in clinical practice in cardiac, vascular and metabolic medicine. The School also hosts activities of the MRC/BHF Centre of Excellence for Advanced Cardiac Therapeutics (REACT) and the BHF Centre of Research Excellence at Kings.