Principal Scientist (m/f/d)

GlaxoSmithKline; Berlin; Vor Ort; EUR 70.000 - 90.000; Vollzeit

Zusammenfassung

A global biopharma company is seeking a Principal Scientist to join their innovative team in Berlin. This role focuses on developing cutting-edge in vitro models using patient-derived organoids for drug discovery in oncology. Ideal candidates will have a Ph.D. and a strong background in cell biology and molecular engineering, combined with proven experience in a collaborative research environment. Competitive compensation and opportunity for impact in patient health are offered.

Qualifikationen

• Several years of postdoctoral or equivalent research experience.
• Strong background in cell biology including complex cell culture techniques.
• Proven expertise with patient-derived organoids.

Aufgaben

• Plan and conduct chemosensitivity assays on organoids.
• Develop protocols for molecular engineering approaches.
• Establish and execute cell culture protocols for organoids.

Kenntnisse

Cell Biology

Molecular Engineering

Disease Modeling

Complex Cell Culture

Effective Communication

Ausbildung

Ph.D. in Cell Biology, Oncology, or related field

Tools

Liquid Handling Systems

Jobbeschreibung

Principal Scientist (m/f/d) - Oncology

Location: Berlin

We are looking for a Principal Scientist to join the newly established NiV (Novel in vitro Phenomics) team. This role is ideal for someone passionate about developing innovative in vitro models and using them for drug development and discovery projects that drive meaningful impact for patients.

NiV is part of the Oncology Translational Research (OTR) team at GSK and is embedded in a collaborative network across OTR and beyond, supporting both preclinical and clinical development programs within the GSK Oncology Therapeutic Area.

The successful candidate will join a team currently being built across Berlin and Stevenage, with a core focus on establishing cutting‑edge organoid models and leveraging them across a range of translational applications, from chemosensitivity profiling to molecular engineering approaches for biomarker discovery and target validation.

Key responsibilities

• Plan and conduct chemosensitivity assays on patient‑derived organoids in small- and large-scale screens including use of liquid handling systems.

• Develop protocols of molecular engineering approaches in patient‑derived organoids and perform subsequent experiments with the team.

• Establish and execute cell culture protocols for the growth and expansion of patient‑derived organoids from various tumor entities.

• Organize and contribute to collaborative projects with internal and external research partners.

• Advise and implement processes adhering to quality control standards.

• Coordinate workflows as part of a cross‑functional project team.

• Collect, analyze, and interpret experimental results; summarize findings in clear reports and presentations for both internal and external stakeholders.

Qualifications & Skills

• Ph.D. in Cell Biology, Oncology, Molecular Biology, or a related field, with several years of postdoctoral or equivalent research experience.

• Strong background in cell biology, including molecular engineering, disease modeling and complex cell culture, ideally with multidisciplinary training.

• Proven expertise in cell culture techniques, particularly with primary samples (human biopsies, resections) and patient‑derived organoids.

• Skilled in cellular and molecular biology methods relevant to translational research.

• Independence in forming scientific hypotheses; executing, analyzing, validating results and optimizing procedures when needed.

• Effective communicator with the ability to collaborate across disciplines and engage with both peers and senior stakeholders.

• Ability to deliver high quality, consistent results in a timely fashion.

Preferred Qualifications & Skills

• Experience with utilization of liquid handling systems and automation of workflows.

• Hands‑on experience in molecular manipulation (e.g., nucleofection, CRISPR) on organoids is an advantage.

• Experience in cellular profiling methods (e.g., flow cytometry analysis) and FACS sorting.

• Experience with variations of culture systems (2D, 3D and/or co‑culture).

• Proven track record of scientific publications or achievements.

• Experience collaborating with biopharmaceutical industry partners.

Find out more:

• Our approach to R&D
• Annual Report
• Product Pipeline

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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