Postdoctoral Fellow – Molecular Neuroscience of Parkinson's Disease

Kalia Laboratory; Toronto; On-site; CAD 60,000 - 80,000; Full time

Job summary

A leading research lab in Toronto is seeking a postdoctoral fellow to investigate molecular mechanisms underlying neuronal death in Parkinson's disease. The position involves molecular neuroscience techniques and developing disease-modifying therapies. Ideal candidates will have a Ph.D. and a strong research background in neurodegeneration. Excellent training environment and support are provided.

Benefits

Access to state-of-the-art research infrastructure

Qualifications

• Candidates must hold a Ph.D. (or equivalent) by the start date.
• Strong record of research productivity is required.
• Prior experience in neuroscience or molecular mechanisms of neurodegeneration is preferred.

Responsibilities

• Develop and apply tools for understanding molecular mechanisms underlying neuronal death.
• Contribute to the discovery of disease-modifying therapies for Parkinson's disease.

Skills

Molecular neuroscience techniques

Cell culturing (including iPSCs)

Working with animals

Protein quality control mechanisms

Drug discovery and therapeutic development

Education

Ph.D. or equivalent

Tools

Molecular biology techniques

2D and 3D organoid systems

Job description

The Kalia Labs in Toronto, Canada, are recruiting a postdoctoral fellow to join our collaborative and multidisciplinary team located in the Krembil Brain Institute at the University Health Network (UHN).

Our research focuses on understanding the molecular mechanisms underlying neuronal death in Parkinson's disease (PD) and discovering much-needed disease-modifying therapies. We aim to revolutionize PD treatment by targeting key processes like protein quality control and developing novel therapeutic approaches.

To explore these questions, we develop and apply an integrated set of tools and approaches, including:

• Molecular biology techniques for dissecting disease mechanisms.
• iPSC-derived 2D cultures and 3D organoids for disease modeling and drug screening.
• In vivo vertebrate animal models to study pathology and test therapies.
• Advanced techniques for investigating protein misfolding and clearance pathways.

We offer a rigorous and supportive training environment within a world-class research ecosystem, fostering innovation and translational science. As part of UHN and affiliated with the University of Toronto, the Kalia Labs provide excellent postdoctoral support and access to state-of-the-art research infrastructure in a vibrant city.

Qualifications and Areas of Interest

We welcome candidates with diverse backgrounds and interests. Particularly encouraged are applicants with demonstrated proficiency in or enthusiasm for:

• Molecular neuroscience techniques relevant to neurodegeneration.
• Cell culturing, including iPSCs, and the development of 2D and 3D organoid systems.
• Working with animals, particularly in vivo vertebrate models for disease modeling and therapeutic testing.
• Protein quality control mechanisms and neurodegeneration.
• Drug discovery and therapeutic development.

Candidates must hold a Ph.D. (or equivalent) by the start date and have a strong record of research productivity. Prior experience in neuroscience or molecular mechanisms of neurodegeneration is preferred.

To Apply

Please send:

• Curriculum vitae
• Brief cover letter describing your research background, interests, and goals, specifically highlighting your experience with molecular neuroscience techniques, cell culturing (including iPSCs), and animal work.
• Contact information for three references

Informal inquiries are welcome.

Contact:

• Dr. Suneil K. Kalia ([e-mail]) Senior Scientist, Krembil Brain Institute, University Health Network Associate Professor, Division of Neurosurgery, Department of Surgery, University of Toronto
• Dr. Lorraine V. Kalia ([e-mail]) Senior Scientist, Krembil Brain Institute, University Health Network Associate Professor, Division of Neurology, Department of Medicine, University of Toronto

Lab website:www.kalialabs.org/