Senior Scientist, Protein Analysis

Chugai Pharmabody Research Pte Ltd; Singapore; On-site; SGD 60,000 - 80,000; Full time

Job summary

An innovative biopharmaceutical company in Singapore is looking for a Senior Scientist specializing in protein analysis. This role involves leading antibody characterization from screening to developability and requires a Ph.D. with relevant experience. The ideal candidate will collaborate with multidisciplinary teams to develop cutting-edge protein analysis technologies while ensuring data integrity and compliance. This position offers a dynamic work environment focused on drug innovation.

Qualifications

• Ph.D. in a relevant field with 0-2+ years of experience in monoclonal antibody drug discovery.
• Strong expertise in protein-protein interaction and binding kinetic analysis.
• Ability to work in a fast-paced and collaborative environment.

Responsibilities

• Lead antibody binding affinity screening using SPR.
• Plan and execute antibody/ligand binding analyses.
• Conduct biophysical analyses for antibody evaluation.

Skills

Protein-protein interaction analysis

Binding kinetic and affinity analysis

Physicochemical characterization of monoclonal antibodies

Good proficiency in spoken and written English

Education

Ph.D. in Biophysics, Biochemistry, or related field

Tools

SPR (Surface Plasmon Resonance)

BLI (Biolayer Interferometry)

Column chromatography

DLS (Dynamic Light Scattering)

Job description

About the role

We are seeking a Senior Scientist with deep expertise in protein analysis to lead antibody characterization across discovery and optimization, from high-throughput screening through developability. Reporting to the Research Manager, you will drive assay development and data generation, collaborate closely with cross-functional teams, and contribute to novel protein analysis technology development. After initial training, you are expected to independently manage antibody analysis.

Key Responsibilities

• Lead antibody binding affinity screening using SPR.
• Plan and execute antibody/ligand binding analyses.
• Plan and conduct biophysical analyses to evaluate physicochemical properties of antibodies.
• Assess developability and manufacturability of antibody drug candidates.
• Support projects from high-throughput screening to late-stage developability assessment, collaborating with multidisciplinary teams to achieve project milestones.
• Contribute to the development and implementation of novel protein analysis technologies.

Required Qualifications

• Ph.D. in Biophysics, Biochemistry, Structural Biology, Biomedical Science, Chemical Biology, Biotechnology, Life Science, or Pharmaceutical Science, or a related scientific field with 0 – 2+ years of relevant industry or research experience, preferably in monoclonal antibody drug discovery.
• Strong expertise in protein-protein interaction analysis, binding kinetic and affinity analysis and physicochemical characterization of monoclonal antibodies.
• Hands‑on experience in at least one of the following areas:
  • Protein–protein interaction analysis (SPR, BLI, GCI)
  • Column chromatography (ion‑exchange, size‑exclusion, reversed‑phase)
  • Biophysical characterization (DLS, DSC, solubility, viscosity, stability testing)
  • Protein LC–MS analysis
• Ability to work in a fast‑paced and collaborative environment
• Strong problem‑solving skills and ability to work independently and in team settings
• Good proficiency in spoken and written English.

The ideal candidate

• Demonstrates a strong passion for medical science and drug innovation.
• Capable of independently running and troubleshooting assays, optimizing methods, and adopting new technologies.
• Ensures data integrity, safety, and compliance with SOPs.
• Skilled in data analysis, visualization, and clear communication to diverse audiences.
• Effective in planning, meeting deadlines, and collaborating across teams.

Application Procedures

Interested applicants are invited to apply now with their detailed resume stating their qualifications, availability, current and expected salary.