Senior Research Fellow/Research Fellow (Medicine)

National University of Singapore; Singapore; On-site; SGD 80,000 - 120,000; Full time

Job summary

A leading educational institution in Singapore is recruiting a full-time Senior Research Fellow/Research Fellow for the Metabolic Liver Disease Lab. The successful candidate will have the opportunity to coordinate multiple wet lab projects, collaborate with various teams, and contribute to advancing research in metabolic dysfunction-associated fatty liver disease. This position requires a PhD with relevant post-doctoral experience and a strong understanding of molecular biology techniques.

Qualifications

• 3 years relevant post-doctoral experience.
• Understanding of MAFLD and obesity-related molecular/cellular mechanisms.
• Experience in handling 2D and 3D cell cultures.
• Familiarity with murine models is a plus.

Responsibilities

• Coordinate and lead multiple wet lab projects.
• Facilitate team development for in vitro assays.
• Conduct data analysis ensuring data validity.
• Assist with ethics/grant application writing.
• Organize and publish findings.

Skills

Molecular biology

RNA/protein extraction

qPCR

Cell culture

Gene perturbation tools

Excellent communication

Education

PhD

Tools

CRISPR/Cas9

Western blotting

Multi-omics analysis

Job description

Job Description

The Yong Loo Lin School of Medicine (NUS) is recruiting a full-time Senior Research Fellow/Research Fellow (1 year contract, renewable).

Purpose of the Post

The National University of Singapore invites applications for a Senior Research Fellow/Research Fellow for the Metabolic Liver Disease Lab in the Department of Medicine, Yong Loo Lin School of Medicine. This role explores functional genomic methods to understand better the molecular mechanisms of metabolic dysfunction-associated fatty liver disease (MAFLD). The Post Doc Scientist will have the opportunity to collaborate with various teams across the School of Medicine, including pathologists, hepatologists, and data scientists. The candidate should demonstrate technical experimental excellence as well as the capacity to lead the research team regarding research projects aimed at producing clinically translational applications.

Responsibilities

• Assist PI in coordinating and leading multiple wet lab projects, proposing research directions and meeting key project milestones.
• Assist PI to facilitate research team development, optimization, and validation of in vitro mammalian cell-based assays related to metabolic diseases (e.g. cell culture, RNA/protein extraction, qPCR, western blotting and other metabolic-related assays).
• Perform other related duties incidental to the work described herein such as conduct data analysis, ensure the validity and reliability of data, maintain accurate and complete records of all findings, and present findings to colleagues.
• Assist PI with writing for ethics/grant applications.
• Assist PI with organising and publishing findings in high impact academic journals of good reputation.

Qualifications

• A PhD with 3 years relevant post‑doctoral experience.
• Understanding of the molecular/cellular basis of MAFLD, obesity and T2D, e.g. lipid metabolism dysregulation, insulin resistance, inflammatory pathways is desired.
• Experience in handling 2D and 3D cell cultures such as hepatocytes, adipocytes or skeletal muscle cells is essential.
• Molecular biology skills (RNA/protein extraction, qPCR, western blotting, IF) are essential.
• Cell line and clinical data multi‑omics familiarity (e.g. transcriptomics, proteomics analysis) is a strong plus.
• Experience with gene perturbation tools such as siRNA, shRNA and CRISPR/Cas9 is a strong plus.
• Experience working with murine models is a strong plus.
• Excellent writing, communication and presentation skills in English.
• Highly organized and skilled in working independently and creatively to solve experimental problems within time constraints.
• Ability to oversee research directions for multiple projects and work in a multidisciplinary team.

Application Instructions

Applicants should send the following documents by email to [HIDDEN TEXT] and please mention "Application for Senior Research Fellow - Metabolic Liver Disease Lab" in your email subject line:

• Cover letter highlighting relevant experience and career goals.
• Curriculum Vitae, including details of three named referees.
• A complete NUS Personal Data Consent for Job Applicants (the form is available at NUS Personal Data Consent for Job Applicants).

Location

Kent Ridge Campus

Organization

Yong Loo Lin School of Medicine

Department

Medicine

Employee Referral Eligible

No

Job Requisition ID

30593