Scientist II (Antibody Design), EDDC

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 70,000 - 120,000; Full time

Job summary

A leading biomedical research institute in Singapore is looking for a proactive and detail-oriented scientist to focus on antibody engineering and functional evaluation. This role involves conducting molecular cloning, performing cell-based assays, and supporting prototype generation. Candidates should hold a B.Sc., M.Sc., or Ph.D. in a relevant field with substantial hands-on experience in molecular biology, immunoassays, and data analysis. Strong analytical skills and ability to work collaboratively are essential. Join us to contribute to transformative research in biologics.

Qualifications

• Minimum 8 years experience with B.Sc., 5 years with M.Sc., or 3 years with Ph.D.
• Hands-on experience in molecular biology techniques.
• Proficient in immunoassays and protein expression systems.

Responsibilities

• Conduct molecular cloning, protein expression, and purification.
• Perform and optimize cell-based functional assays.
• Collaborate with scientists and ensure timely delivery of milestones.

Skills

Molecular biology

Mammalian cell culture

Immunoassays (ELISA, FACS)

Analytical mindset

Team collaboration

Data analysis software (GraphPad, FlowJo, Python/R)

Education

B.Sc., M.Sc., or Ph.D. in Biological Sciences, Biochemistry, Immunology

Tools

SEC-MALS

BLI

SPR

HPLC

Automation systems

Liquid-handling platforms

Job description

We are seeking a proactive and detail-oriented scientist to support antibody engineering and functional evaluation within our next-generation biologics immune engager platform. This role focuses on experimental execution, assay development and molecular prototyping, contributing to programs with strong translational and partnership potential.

Position Impact

These positions form part of the Antibody Technology core, driving institutional innovation in next-generation antibody and immune‑engager platforms that underpin future co‑development partnerships and spin‑off opportunities. Successful candidates will play a vital role in transforming scientific concepts into translatable therapeutic asset.

Key Responsibilities

• Conduct molecular cloning, protein expression, purification, and analytical characterization of antibody immune‑engager candidates.
• Perform and optimize cell‑based functional assays to assess potency, signaling, and immune activation.
• Support mono‑specific and multi‑specific prototype generation, screening, and data collection to evaluate molecular performance and mechanism of action.
• Maintain accurate experimental records, perform quantitative analysis, and contribute to internal data reviews and reports.
• Collaborate closely with scientists and engineers across discovery, design, and assay teams to ensure quality and timely delivery of milestones.
• Uphold high laboratory and data standards, contributing to a rigorous and collaborative team environment.

Experience & Qualifications

• B.Sc., M.Sc., and Ph.D. in Biological Sciences, Biochemistry, Immunology, or related field, with minimum of 8 years BSc, 5 years MSc, 3 years PhD, and relevant hands‑on experience.
• Practical skills in molecular biology, mammalian cell culture, and immunoassays (ELISA, FACS, reporter, cytotoxicity).
• Experience with protein expression systems (transient or stable) and purification workflows preferred.
• Strong analytical mindset, attention to detail, and ability to troubleshoot experiments independently.
• Team player with good communication, adaptability, and eagerness to learn new technologies in a fast‑paced translational research setting.
• Experience with automation systems, liquid‑handling platforms, or high‑throughput screening.
• Working knowledge of data analysis software (e.g., GraphPad, FlowJo, Python/R) for experimental interpretation.
• Familiarity with protein characterization techniques (SEC‑MALS, BLI, SPR, HPLC).
• Understanding of immune‑cell biology or cytokine signaling mechanisms.
• Strong initiative, reliability, and enthusiasm to contribute to high‑impact discovery programs.
• Prior experience in computational modelling is an advantage.