Senior Scientist, Protein Characterisation & LC-MS/MS

IMMUNOCORE LTD; North Cerney; On-site; GBP 60,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I to drive characterisation work within CMC. You will develop and apply HPLC-based peptide mapping and mass spectrometry methods to characterize recombinant proteins and antibodies, including glycosylation analysis and post-translational modifications.

You will coordinate testing of protein biomolecules, work with microbial and mammalian expression systems, and contribute to process development and method development for ImmTAX and related products.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.
• Experienced in assay development.

Responsibilities

• Characterise proteins/biopharmaceuticals using peptide mapping (LC-MS/MS) and mass spectrometry.
• Support impurity characterisation and identification for drug substances and products.
• Contribute to development of characterisation methods for ImmTAX and other products.
• Lead or mentor team members; propose new experiments based on data.

Skills

HPLC peptide mapping

Mass spectrometric characterisation

Glycosylation analysis

Protein biomolecule testing

Post-translational modification

Assay development

Biopharmaceutical stability

Bench-based biopharma lab work

Education

BSc/ MSc in biochemistry/ biotechnology

PhD in related discipline

Tools

LC-MS/MS

HPLC

Mass spectrometers

Job description

Immunocore is seeking a Senior Scientist I to drive characterisation work within CMC. You will develop and apply HPLC-based peptide mapping and mass spectrometry methods to characterize recombinant proteins and antibodies, including glycosylation analysis and post-translational modifications.

You will coordinate testing of protein biomolecules, work with microbial and mammalian expression systems, and contribute to process development and method development for ImmTAX and related products.