Senior Scientist I - Protein Characterisation & MS

IMMUNOCORE LTD; Stratford-on-Avon; Presencial; GBP 60.000 - 90.000; Jornada completa

Descripción de la vacante

Immunocore is seeking a Senior Scientist I in Characterisation to drive analytical characterisation of biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis. You will design experiments, execute HPLC-based mapping, and interpret data to support development of ImmTAX and other biologics.

The role requires hands-on experience with chromatographic and mass spectrometric techniques across microbial and mammalian expression systems, collaboration across teams, and

Formación

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices increasing efficiency.

Responsabilidades

• Characterise protein biomolecules and perform peptide mapping (LC-MS/MS) and mass spectrometry analyses.
• Support development of characterisation methods for biopharmaceutical products.
• Contribute to stability and impurity analysis of drug substances and products.
• Provide technical guidance and mentorship to colleagues on analytical techniques.

Conocimientos

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Assay development

Stability studies

Team collaboration

Educación

BSc/MSc in Biochemistry/Biotechnology or related

PhD (desirable)

Descripción del empleo

Immunocore is seeking a Senior Scientist I in Characterisation to drive analytical characterisation of biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis. You will design experiments, execute HPLC-based mapping, and interpret data to support development of ImmTAX and other biologics.

The role requires hands-on experience with chromatographic and mass spectrometric techniques across microbial and mammalian expression systems, collaboration across teams, and