Senior Scientist I, Protein Characterisation & MS

IMMUNOCORE LTD; South Moreton; On-site; GBP 55,000 - 75,000; Full time

Job summary

Immunocore Ltd. in Oxford is seeking a Senior Scientist I in Characterisation to advance analytical methods for biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis.

You will support drug substance and product impurity characterisation and contribute to process development. You will apply expertise in HPLC-based peptide mapping and protein MS, design and execute assays, mentor colleagues, and present findings to senior management, while upholding safety, quality, and

Qualifications

• Essential: Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Essential: Experience of glycosylation analysis of recombinant proteins or antibodies.
• Essential: Independently coordinated extensive testing of protein biomolecules.
• Essential: Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Essential: Understanding of expected post-translational modifications in biological systems.
• Essential: Worked in a bench-based biopharmaceutical laboratory environment.
• Essential: Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.
• Essential: Experienced in assay development.
• Essential: Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Essential: Worked and contributed actively in a diverse team environment.
• Essential: Proposed and driven changes in working practices that improved efficiency.

Responsibilities

• Characterise proteins and recombinant biopharmaceuticals using peptide mapping and mass spectrometry.
• Support impurity characterisation of drug substance and product.
• Contribute to development of characterisation methods for ImmTAX and related products.
• Design and perform biochemical characterisation, stability and comparability studies.
• Contribute to study protocols, reports, and data interpretation.

Skills

HPLC peptide mapping

Mass spectrometry of proteins

Glycosylation analysis

Protein characterization

Biopharmaceutical lab work

Mentoring teams

Data presentation

Education

BSc or MSc in biochemistry/biotech

PhD desirable

Tools

LC-MS/MS instrumentation

HPLC systems

Job description

Immunocore Ltd. in Oxford is seeking a Senior Scientist I in Characterisation to advance analytical methods for biopharmaceuticals, including peptide mapping (LC-MS/MS) and intact mass analysis.

You will support drug substance and product impurity characterisation and contribute to process development. You will apply expertise in HPLC-based peptide mapping and protein MS, design and execute assays, mentor colleagues, and present findings to senior management, while upholding safety, quality, and