Senior Scientist I - Protein Characterisation & MS

IMMUNOCORE LTD; South Oxfordshire; On-site; GBP 55,000 - 75,000; Full time

Job summary

Immunocore is a pioneering, commercial-stage biotechnology company advancing T cell receptor-based therapies. We seek a Senior Scientist I to develop and apply characterisation methods for our biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass analysis.

You will support impurity characterisation, glycosylation analysis, and method development in a fast-paced, collaborative Oxford site environment. Mentoring may be involved.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.

Responsibilities

• Characterise protein biomolecules and perform peptide mapping (LC-MS/MS) and intact mass analysis.
• Support drug substance and drug product impurity characterisation and identification.
• Carry out glycosylation analysis and protein sequence modification identification.
• Contribute to method development for ImmTAX and related products.
• Document study protocols and reports; present findings to the team.

Skills

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Bench biopharma

Education

BSc/MSc in biochemistry

PhD desirable

Tools

HPLC

Mass spectrometer

Job description

Immunocore is a pioneering, commercial-stage biotechnology company advancing T cell receptor-based therapies. We seek a Senior Scientist I to develop and apply characterisation methods for our biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass analysis.

You will support impurity characterisation, glycosylation analysis, and method development in a fast-paced, collaborative Oxford site environment. Mentoring may be involved.