Senior Scientist I, Protein Characterisation & MS

IMMUNOCORE LTD; Lower Assendon, Ovingdean; On-site; GBP 55,000 - 75,000; Full time

Job summary

Immunocore Ltd in Oxford is seeking a Senior Scientist I to drive characterisation of biotherapeutic proteins within the CMC scope. You will develop LC-MS/MS peptide mapping and intact mass analysis methods, while supporting impurity characterisation and process development for ImmTAX products.

The role requires hands-on bench work in a biopharmaceutical lab, with opportunities to mentor colleagues and present findings to internal and external audiences.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic or chromatographic or mass spectrometry.
• Experienced in assay development
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and supported teams through adoption.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise biotherapeutic proteins using peptide mapping and mass spectrometry.
• Support impurity characterisation of drug substance and product.
• Contribute to development of characterisation methods for ImmTAX and products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Design and perform biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Write study protocols and reports.
• Present findings to colleagues, senior management and partners.
• Mentor teammates and share knowledge across departments.
• Adhere to safe working practices in laboratories and maintain records.
• Provide technical guidance on equipment usage and methods.

Skills

Peptide mapping

Glycosylation analysis

Protein characterisation

Microbial expression

Mammalian expression

Post-translational mods

Bench laboratory work

Electrophoresis

Chromatography

Mass spectrometry

Assay development

Stability studies

Team collaboration

Education

BSc/ MSc in Biochemistry or Biotechnology

PhD desirable

Tools

LC-MS/MS

HPLC

Mass spectrometry

Job description

Immunocore Ltd in Oxford is seeking a Senior Scientist I to drive characterisation of biotherapeutic proteins within the CMC scope. You will develop LC-MS/MS peptide mapping and intact mass analysis methods, while supporting impurity characterisation and process development for ImmTAX products.

The role requires hands-on bench work in a biopharmaceutical lab, with opportunities to mentor colleagues and present findings to internal and external audiences.