Senior Scientist I, Protein Characterisation & Mass Spec

IMMUNOCORE LTD; Mill End; On-site; GBP 60,000 - 80,000; Full time

Job summary

Immunocore is a pioneering T cell receptor biotechnology company seeking a Senior Scientist I - Characterisation within CMC in Oxford. You will apply peptide mapping LC-MS/MS and intact mass analysis to characterise biopharmaceutical products, guiding development and analytical strategies.

You will support impurity characterisation, glycosylation analysis, and process development, while mentoring colleagues and delivering study reports to senior stakeholders.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in one or more of the following areas: o electrophoretic o chromatographic o mass spectrometry
• Experienced in assay development
• Familiar with biopharmaceutical stability study principles and interpretation thereof
• Worked and contributed actively in a diverse team environment
• Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
• Presented detailed scientific findings and papers to internal and external audiences

Responsibilities

• Characterisation of biopharmaceutical proteins using peptide mapping (LC-MS/MS) and intact mass analysis.
• Support drug substance and drug product impurity characterisation and identification.
• Contribute to development of characterisation methods for ImmTAX and other products.
• Design and carry out biochemical characterisation and stability studies of biologics.
• Write study protocols and reports; present findings to teams and partners.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Assay development

Bench-based lab

Education

BSc in biochemistry / related

MSc in biotechnology / related

PhD (Desirable)

Job description

Immunocore is a pioneering T cell receptor biotechnology company seeking a Senior Scientist I - Characterisation within CMC in Oxford. You will apply peptide mapping LC-MS/MS and intact mass analysis to characterise biopharmaceutical products, guiding development and analytical strategies.

You will support impurity characterisation, glycosylation analysis, and process development, while mentoring colleagues and delivering study reports to senior stakeholders.