Senior Scientist, Protein Characterisation & Mass Spec

IMMUNOCORE LTD; Upper Boddington; On-site; GBP 70,000 - 100,000; Full time

Job summary

Immunocore is a pioneering biopharma company seeking a Senior Scientist I - Characterisation in the CMC group at its Oxford site. The role centers on developing peptide mapping (LC-MS/MS) and intact mass spectrometry methods to characterise biopharmaceutical products.

You will support impurity characterisation, glycosylation analysis, and method development for ImmTAX and related products, while mentoring colleagues and contributing to study protocols and reports.

Qualifications

• Experience in development of HPLC-based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in one or more of the following areas: electrophoretic, chromatographic, mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise proteins and process intermediates using LC-MS/MS and other methods.
• Develop and char methods for ImmTAX and related products.
• Maintain laboratory records and ensure compliance.
• Mentor colleagues and share knowledge across the department.
• Present research findings to management and partners.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Assay development

Biopharmaceutical stability

Mentoring

Data presentation

Education

BSc/MSc in biochemistry/biotechnology

PhD in related discipline

Tools

LC-MS/MS

HPLC

Mass spectrometry platforms

Job description

Immunocore is a pioneering biopharma company seeking a Senior Scientist I - Characterisation in the CMC group at its Oxford site. The role centers on developing peptide mapping (LC-MS/MS) and intact mass spectrometry methods to characterise biopharmaceutical products.

You will support impurity characterisation, glycosylation analysis, and method development for ImmTAX and related products, while mentoring colleagues and contributing to study protocols and reports.