MRC Postdoctoral Research Scientist

MRC Laboratory of Medical Sciences; City Of London; On-site; GBP 42,000 - 50,000; Full time

Job summary

A leading biomedical research institution in London seeks a Postdoctoral Research Scientist in Chromatin and Development. The role involves supporting projects on metabolism and epigenetic regulation within the lab. Suitable for candidates with a PhD in gene regulation or chromatin biology, with experience in embryonic stem cells desirable. This fixed-term contract offers a salary of £42,694 plus allowances, with applications due by December 2, 2025.

Benefits

Defined benefit pension scheme

30 days holiday plus bank holidays

Family-friendly policies

Shopping/travel discounts

Health and Wellbeing Support

Salary sacrifice cycle to work scheme

Qualifications

• Experience in gene regulation or chromatin biology.
• Prior experience in embryonic stem cell culture and/or mouse embryology is highly desirable.
• Skills in techniques of gene and chromatin regulation such as CRISPR, CutTag, CutRun, ATAC-seq.

Responsibilities

• Support 1-2 projects during maternity leave and paper revisions.
• Work on metabolism and epigenetic regulation of early mouse development.
• Lead and contribute to important research projects.

Skills

Gene regulation

Chromatin biology

Developmental biology

Embryonic stem cell culture

CRISPR

CutTag

CutRun

ATAC-seq

Education

PhD in a related biological field

Job description

MRC Postdoctoral Research Scientist

Chromatin and Development

Salary: £42,694 plus London allowances £5,560 per annum*

Fixed term for 18 months

London, UK

About us

The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS is one of three directly funded MRC research institutes and enjoys close links with our partners at Imperial College London and the Imperial College Healthcare NHS Trust.

About the role

We are seeking an enthusiastic and reliable Postdoctoral Researcher to join the Chromatin and Development group and support 1-2 projects during maternity leave and paper revisions. These projects cover the exciting topics of metabolism and epigenetic regulation of early mouse development and chromatin biology. The ideal candidate will be a talented bench scientist who is collaborative and keen to lead and contribute to some important pieces of work within the lab. This position would suit someone looking for a short-term postdoc and the chance to work on 1-2 papers. Alternatively, depending on CV and success, the candidate will be supported to apply for external funding to continue a longer postdoc in the lab and continue the work.

About you

The ideal candidate will have a PhD (or equivalent experience) in gene regulation, chromatin biology, development or a related biological field. Prior experience of embryonic stem cell (ESC) culture and/or mouse embryology is highly desirable, as is experience with techniques in gene and chromatin regulation such as CRISPR, CutTag, CutRun, ATAC-seq. One project focuses on determining the mechanistic link between metabolite compartmentalization and mouse ESC chromatin and cell fate. The second project involves regulation of chromatin reprogramming in early mouse embryos. Ideally, a candidate would have the experience and/or skills to contribute to both projects; however only one is essential. The position is available to be filled January 2026. Owing to the recruitment time, it is unlikely sponsorship of a visa is possible.

What we offer

As well as the exciting opportunities this role presents, we also offer defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more -Benefits

How to apply

For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/3059 and upload your CV, names and contacts of two scientific references along with a cover letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be accepted. Please quote reference number LMS 2743

*Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two which will be adjusted accordingly.

Closing date: 2 December 2025

Final appointment will be subject to pre-employment screening

Please note that applications may be reviewed by both LMS and Imperial staff