Clinical Trial Manager - Sponsor dedicated

Syneos Health, Inc.; Remote; GBP 40,000 - 60,000; Full time

Job summary

A biopharmaceutical solutions organization in London seeks a Clinical Trial Manager to oversee site management and ensure clinical trial compliance. Responsibilities include managing clinical monitoring, reviewing project scopes, and collaborating with teams to meet study milestones. The ideal candidate holds a relevant degree and has expertise in site management and monitoring, along with excellent communication and problem-solving skills. Join an agile team driven to improve patient outcomes globally.

Benefits

Career development opportunities

Comprehensive benefits programs

Supportive company culture

Qualifications

• Bachelor's degree or RN in a related field or equivalent.
• Ability to lead teams to achieve project milestones.
• Expertise in site management and monitoring.
• Understanding of clinical trial management principles.

Responsibilities

• Oversight of site management and clinical monitoring.
• Review project scope and budget.
• Collaborate with teams to meet study milestones.
• Ensure compliance with GCP and regulatory standards.

Skills

Strong communication skills

Problem-solving

Risk management

Conflict resolution

Education

Bachelor’s degree or RN in a related field

Tools

CTMS

EDC

Microsoft Office

Job description

Overview

Clinical Trial Manager - Sponsor dedicated (Remote, with travel))

Updated: January 20, 2026

Location: London, LND, United Kingdom

Job ID: 25105121

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities. Our Clinical Development model centers the customer and the patient, with an emphasis on simplification and streamlined processes. Whether you join in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies because we are passionate about changing lives.

Discover what our 29,000 employees across 110 countries already know:

Get to know Syneos Health

• We are passionate about developing our people through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to our Total Self culture – where you can authentically be yourself. Our Total Self culture unites us globally, and we are dedicated to taking care of our people.
• We are continuously building the company we all want to work for and our customers want to work with. Diversity of thoughts, backgrounds, cultures, and perspectives helps everyone belong.

Job Responsibilities

• Responsible for site management oversight, clinical monitoring and central monitoring deliverables with a focus on patient safety, protocol/GCP/regulatory compliance and data integrity.
• Oversees site interactions post activation through site closeout, including patient recruitment, investigator payments or other related activities.
• Identifies critical data and process risks and mitigations related to the completion of the Risk Assessment and Categorization Tool (RACT).
• Reviews the study scope of work, budget and protocol content; ensures the clinical project team (CRAs/Central Monitors) is aware of contractual obligations and parameters.
• Uses prior clinical experience, operational data, metrics and reports to identify risks to clinical trial management deliverables.
• Escalates to the project manager any risks to clinical trial management deliverables (timeline, quality and budget) and activities/requests outside contracted scope.
• Proposes and implements risk mitigations using strategic thinking and problem-solving skills.
• Participates and presents in key meetings such as Kick Off Meeting.
• Serves as an escalation point for communications with investigator site staff and may interact with principal investigators or other site staff members. May accompany CRA team members to sites for observation or conflict resolution.
• Collaborates with Study Start Up, Patient Recruitment and Data Management to coordinate delivery handoffs and meet study milestones (site activation targets, enrollment targets, database lock timelines). Reviews and provides feedback on related functional plans (e.g., Data Management Plan, Communication Plan).
• Responsible for development and ongoing maintenance of clinical study tools and templates, including the Clinical Monitoring Plan. Ensures CTMS, dashboards and other systems are set up and available for the team; oversees user acceptance testing (UAT) as needed and conducts access/audit trail reviews as required.
• Coordinates initial and ongoing training to the study team on protocol specifics, Case Report Form completion, dashboards, Sponsor SOPs, clinical plans and guidelines, data plans and timelines.
• Oversees resourcing allocations for CRAs and Central Monitors, site assignments and conduct, and identifies risks to delivery or quality.
• Ensures the quality of clinical monitoring, central monitoring and site management deliverables within a project and maintains visibility of progress using approved systems/tools.
• Reviews project oversight dashboards and systems (CTMS, EDC, eDiary, ePROs, TMF, IVRS/IWRS, Central Monitoring dashboards) to oversee site and patient activities and ensure data reflect timely execution of operational aspects (visits/calls, duration, frequency) as planned.
• Understands the monitoring strategy for the study and participates in developing the study risk assessment plan. Accountable for assigned team members’ understanding, compliance and delivery according to the monitoring strategy, CMP/SMP, and risk plans.
• Reviews site and central monitoring documentation (calls, visit reports, letters, central monitoring reports, pertinent correspondence) to ensure they reflect site management activities and communicate risks to protocol/GCP compliance, trial conduct, patient safety or data integrity. Document revisions and approvals in CTMS; ensure delivery deadlines align with sponsor/specifications.
• Interacts with the client and other functional departments related to monitoring, central monitoring and site management activities. Provides status updates and risks as per agreements. Proposes solutions to obstacles in protocol execution and site management.
• Demonstrates understanding of other functions’ roles and ensures compliance and delivery per protocol, SOPs, ICH GCP and country regulations. Supports inspection readiness for clinical trial management scope.
• Oversees CRAs and Central Monitors; assesses process/training compliance and identifies risks. May develop corrective action plans and supports data cut and lock deadlines.
• Provides feedback to line managers on staff performance and may be assigned to larger, more complex trials.

Qualifications

• Bachelor’s degree or RN in a related field or equivalent combination of education, training and experience
• Demonstrated ability to lead and align teams to achieve project milestones
• Demonstrated capability of working in an international environment
• Demonstrated expertise in site management and monitoring (clinical or central)
• Preferred experience with risk-based monitoring
• Understanding of clinical trial management financial principles and budget management
• Knowledge of Good Clinical Practice/ICH Guidelines and other regulatory requirements
• Good computer skills
• Strong communication, presentation and interpersonal skills with project teams and sites
• Strong conflict resolution skills
• Problem-solving, risk management and critical thinking to mitigate issues
• Moderate travel may be required, approximately 20%

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 studies across 73,000 sites and 675,000+ trial patients.

No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.

http://www.syneoshealth.com

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates. The Company supports compliance with the Americans with Disabilities Act, including reasonable accommodations when appropriate to assist employees or applicants to perform essential functions.

Summary

Roles within the Clinical Trial Management job family are responsible for all aspects of the development, coordination, and implementation of Phase 1 clinical research studies. They collaborate with the principal investigator, coordinate between research subjects, client teams, investigators, and clinic operations teams, and plan logistics and resource usage. They track study progress in alignment with project milestones, client deliverables, and budget, following applicable regulations globally and by region.

Discover what our more than 29,000 employees already know: work here matters everywhere. We work hard and smart to bring therapies to those who need them. A career with Syneos Health means your everyday work improves patients’ lives around the world.

Syneos Health® (Nasdaq:SYNH) is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate clinical, medical affairs and commercial insights into outcomes to address modern market realities. We share insights, use the latest technologies and apply advanced business practices to speed our customers’ delivery of important therapies to patients. We support a diverse, equitable and inclusive culture.