Post-doc Synthesis of Active Pharmaceutical Ingredients by mechanochemistry

Universite de Montpellier; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A prominent research institution in France is seeking a Postdoctoral Researcher specializing in organic chemistry to develop sustainable methodologies using mechanochemistry. This role involves designing scalable and eco-friendly routes for pharmaceutical ingredients and requires a doctoral degree in a relevant field, alongside proficiency in synthesis and analytical techniques. The position offers a monthly salary between €2,200 and €2,270 and is based at the Institut Charles Gerhardt Montpellier.

Qualifications

• Strong skills in synthesis and analytical methods.
• Interest in technological aspects of projects.
• Experience in green chemistry and mechanochemistry is a plus.

Responsabilités

• Develop sustainable methodologies for organic synthesis.
• Characterize APIs or key intermediates.
• Investigate mechanochemical process parameters.

Connaissances

Synthesis and analytical methods

Green chemistry

Mechanochemistry

Ball-milling

Resonant Acoustic Mixing

Extrusion technologies

Formation

Doctoral degree in medicinal chemistry or preparative organic chemistry

Outils

NMR

HPLC

MS

IR

Description du poste

Organisation/Company Universite de Montpellier Department Human Resources Research Field Chemistry » Organic chemistry Technology » Chemical technology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 13 Feb 2026 - 23:59 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Horizon Europe Reference Number 2026-R0142 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

- work environment: We are looking for a Post‑Doc who wants to contribute to the successful delivery of APIs or key intermediates by mechanochemistry. A unique opportunity for you to work in a scientific area of great importance, innovative and disruptive, in a setting at the interface with the industrial needs and in close interactions with excellent academic groups members of the European Programme Horizon IMPACTIVE (Innovative Mechanochemical Processes to synthesize ACTIVE pharmaceutical ingredients).

- main mission: The Post doc will work under the responsibility of Dr. Evelina Colacino, on the development of sustainable methodologies for organic synthesis, with a special attention to the preparation of value‑added compounds, mainly by Resonant Acoustic Mixing for the pharmaceutical industry in large‑scale.

- activities: As a Post‑Doc, you will deal with the synthesis and development of APIs or key intermediates mainly by Resonant Acoustic Mixing (RAM), and their characterization (including at the solid state). Your main research objectives will be to propose and design straightforward access (meaning specifically route scouting) to APIs by mechanochemistry, in alternative to solution‑based procedures and to improve the ecological footprint of each synthesis at laboratory and large scales. The daily synthesis work will be performed at the Université de Montpellier (Charles Gerhardt Institute of Montpellier, ICGM) in France.

Research activity will mainly focus on

• Design of scalable and green routes for APIs or key intermediates mainly under RAM in alternative to solution‑based processes currently used in the industry;
• Investigation of the mechanochemical process parameters to access them in batch at different scales, and by ‘parallel mechanochemistry’ at laboratory scale;
• Green Chemistry metrics applied to the processes developed within the project;
• Solid state characterization of each APIs or key intermediates;
• Process development to access new pharmaceutical forms

The net monthly salary is between €2,200 and €2,270

To qualify for the position of Post-Doc, you must have a doctoral degree in a relevant field such as medicinal chemistry, preparative organic chemistry, with solid skills in synthesis and analytical methods (NMR, HPLC, MS, IR, etc.). Candidate should have a strong interest in the technological aspects of the project. Experience in green chemistry, mechanochemistry, ball‑milling, RAM, extrusion technologies and solid state characterization is considered meritorious for this position, but not compulsory.

We are looking for you who can work independently but also in close collaboration with the group members and as a part of the European Programme Horizon IMPACTIVE. You can plan and organize your own work, take your own initiatives and responsibility, be analytical and creative and be able to deliver results in time. You also need to be able to report to the founders, hence, need good communication skills and an interest for multidisciplinary research.

Work Location(s)

Number of offers available 1 Company/Institute Institut Charles Gerhardt Montpellier (ICGM) Country France Geofield