Postdoctoral Scientist assay development, Institute of Translational Medicine and Pharmacology

Universitätsmedizin Frankfurt; Frankfurt; Vor Ort; EUR 60.000 - 80.000; Vollzeit

Zusammenfassung

An academic medical center in Frankfurt is seeking a Postdoctoral Scientist in Assay Development. This position focuses on drug discovery within a collaborative research environment, specifically the Cluster4Future PROXIDRUGS project. Responsibilities include protein production and developing advanced assay technologies. The ideal candidate will have a PhD in life sciences and experience in assay development. The role comes with competitive benefits, fostering professional development and long-term security.

Leistungen

Salary based on collective agreement TV-G-U E13

Long-term security through company pension schemes

Internal and external training for professional development

Health benefits with workshops on nutrition and exercise

Childcare offered in daycare center

Free public transport in Hessen

Access to campus cafés

Qualifikationen

• PhD in biology, biochemistry, molecular biology, cell biology, pharmacology, or an equivalent field.
• Experience in assay development and cell biology required.
• Independently problem-solving with systematic, data-driven experimental design.

Aufgaben

• Perform protein production including cloning, expression, purification, and quality control.
• Develop biophysical and binding assays using advanced techniques.
• Miniaturize and automate assays for high-throughput screening.
• Collaborate with data scientists for result analysis.

Kenntnisse

Assay development

Cell biology

Problem-solving

Data-driven experimental design

Multidisciplinary teamwork

Proficient in English

Ausbildung

PhD in life sciences

Jobbeschreibung

Postdoctoral Scientist, Assay Development – Institute of Translational Medicine and Pharmacology, Universitätsmedizin Frankfurt (Frankfurt am Main, Hesse, Germany)

The project is a close collaboration between Goethe University and the Fraunhofer Institute of Translational Medicine and Pharmacology (ITMP) in Frankfurt and Hamburg. The position will be based in Frankfurt am Main at the Institute of Clinical Pharmacology, Goethe University. It is a fixed‑term appointment for 2 years, with remuneration and social benefits based on the public‑sector collective agreement (TV‑G‑U).

We invite applications for a postdoctoral researcher in the field of assay development, drug discovery and characterization within the Cluster4Future PROXIDRUGS (project ProxiDETECT). The Cluster4Future PROXIDRUGS aims to develop innovative therapies for human diseases by targeted degradation of disease‑relevant proteins within cells. The ProxiDETECT project develops advanced assay technologies and imaging solutions for the identification, biophysical and phenotypic characterization of molecular glues and novel ubiquitin E3 ligase ligands.

Responsibilities

• Protein production (cloning, expression in various systems, purification, quality control)
• Development and application of biophysical/binding assays using techniques such as thermal shift, surface plasmon resonance, biolayer interferometry, spectral shift and ligand displacement assays
• Assay miniaturization and automation
• Screening of medium‑sized small‑molecule compound libraries
• Analysis of results in close collaboration with data scientists, bioinformaticians and chemoinformaticians

Qualifications

• PhD in life sciences – biology, biochemistry, molecular biology, cell biology, pharmacology or an equivalent field
• Experience in assay development and cell biology
• Independently problem‑solving, systematic, data‑driven experimental design and execution
• Proficiency in English (German language skills a plus)
• Enjoyment of multidisciplinary teamwork
• Proof of measles immunity/vaccination required by legal regulations

Benefits

• Salary based on the collective agreement TV‑G‑U E13 with an annual special payment
• Long‑term security through company pension schemes
• Internal and external training for professional development
• Health benefits – regular online and face‑to‑face courses on nutrition, relaxation, sports and exercise
• Part‑time employment possible; childcare offered in our daycare center (including holidays)
• Free public transport in Hessen (Free State Ticket Hessen)
• Uniklinik‑Campus Mensa Cafés

Contact

Prof. Dr. Aimo Kannt

Formal applications consisting of one PDF document including a cover/motivation letter and CV (including contact data for 2–3 referees).

Application Deadline: 24.11.2025

We welcome applications from candidates of all genders. Women are currently underrepresented in these positions at Universitätsmedizin Frankfurt; therefore applications from women are especially encouraged. Applicants with severe disabilities will receive preferential consideration in cases of equal professional qualifications.