Manufacturing Associate Director

AstraZeneca Singapore Pte Ltd; Singapore; On-site; SGD 60,000 - 80,000; Full time

Job summary

A global biopharmaceutical company seeks a Manufacturing Associate Director in Singapore to lead various manufacturing units at a new biologics campus. The candidate will ensure compliance with regulatory standards while driving operational excellence. Key responsibilities include resource management, overseeing manufacturing processes, and enhancing team performance. This is an opportunity to contribute significantly to innovative medical solutions and build a transformative manufacturing operation.

Qualifications

• Experience in start-up and operation in monoclonal antibody production, API chemical manufacturing.
• Technical knowledge of sterile filling and lyophilization.
• Leadership experience guiding multi-functional teams to adhere to safety standards.

Responsibilities

• Lead operational activities for manufacturing, ensuring safety and compliance.
• Drive consistency to regulatory expectations and ensure inspection readiness.
• Manage resources and develop KPIs across productivity, quality, and cost.

Skills

Strategic Planning

Resource Management

Operational Leadership

Compliance readiness

Team Leadership

Coaching and Development

Job description

Job Title: Manufacturing Associate Director

Career level: F

Introduction to role

Be part of history in the making. AstraZeneca is building its first biologics manufacturing campus in Singapore — a groundbreaking USD 1.5 billion investment that will serve as a global hub for innovation and excellence.

This state‑of‑the-art facility will deliver end‑to‑end Antibody‑Drug Conjugate (ADC) capabilities with different manufacturing units/buildings in one campus Small molecule‑ chemical API production

• Large molecule‑ monoclonal antibody manufacturing
• Conjugation
• Fill-and-finish operations, including sterile filling and lyophilization
• Final secondary packaging

The campus will be equipped with modern digital and automation infrastructure, enabling autonomous manufacturing powered by artificial intelligence. In addition, it will be designed for carbon neutrality, embedding sustainability into every aspect of operations and setting a new benchmark for environmentally responsible biologics manufacturing.

We are looking for passionate individuals with relevant experience who thrive in dynamic environments and bring a “make‑it‑happen” attitude. Joining us means contributing to a project that will not only transform AstraZeneca’s global supply chain but also advance life‑changing medicines for patients everywhere.

If you’re ready to shape the future of biologics and be part of a once‑in‑a‑generation project, we want you on our team.

We are recruiting Manufacturing Associate Directors to lead and manage the different manufacturing units across our campus.

Accountabilities

Operational Leadership: Establish and lead all operational activities for the Manufacturing unit including process execution, staffing, safety, compliance readiness and adherence to unit budget.

Design Ownership: Serve as the Manufacturing Unit operational owner during Basic Design and Detailed Design, ensuring operational needs are built into facility and equipment decisions.

Multi-functional Collaboration: Partner with Global Engineering and work across QA, QC, Engineering, and Demand & Supply to shape facility layout and equipment strategy, guiding process and equipment decision-making.

Compliance Leadership: Drive consistency to cGMP, occupational safety and local regulatory expectations, ensuring inspection readiness and sustainable compliance.

Resource Strategy: Plan, manage and control resource allocation to secure future manufacturing capability and deliver strategy.

Improvement and Profitability: Direct new initiatives and improvement programs to strengthen compliance, enable continuous improvement, advance technical excellence and enhance profitability.

Team Leadership: Recruit, set goals and manage performance for a multi‑functional team that delivers to time, cost and quality standards.

Safety and Work Standards: Lead a multi‑disciplinary team to define and achieve manufacturing safety and work standards and associated procedures that meet business needs and satisfy external regulators.

Business Needs to Resources: Define business requirements, gain approvals and translate needs into specific resource plans.

Coaching and Development: Coach and develop all Process Execution team members to build depth, flexibility and engagement.

Senior Stake holder Engagement: Develop senior‑level relationships to resolve issues, optimize business performance and surface future improvement opportunities.

KPI Ownership: Own and drive KPIs across productivity, quality, safety, schedule consistency and cost, using data to prioritize and act.

Culture and Ways of Working: Foster an inclusive, safety‑first environment where ideas are tested, learned from and grown.

Process Capability and Digital: Drive process capability improvement, lean operations and digital automation to reduce variability and accelerate throughput.

Essential Skills/Experience

Strategic Planning & Resource Management

• Ability to define business needs, gain approval and translate these needs into specific resource requirements.
• Experience planning, managing and controlling overall allocation of resources to ensure future capability to implement manufacturing strategy.
• Ability to develop senior‑level contacts to resolve issues, optimize business performance and develop future improvement opportunities.

Facility & Process Design Leadership

• Experience serving as Manufacturing Unit operational owner during Basic Design and Detailed Design phases.
• Demonstrated collaboration with Global Engineering and multi‑functional partners including QA, QC, Engineering, and Demand & Supply to shape facility layout and equipment strategy, guiding process and equipment decision‑making.

Operational Leadership & Execution

• Track record establishing and leading all operational activities for a manufacturing unit, including process execution, staffing, safety and compliance.
• Experience leading a multi‑disciplinary team to define and achieve manufacturing safety and work standards and associated procedures, ensuring assets meet business needs and satisfy external regulators.

Compliance, Quality & Performance Excellence

• Proven ability to drive compliance with cGMP, occupational safety and local regulatory expectations.
• Demonstrated ability to drive process capability improvement, lean operations and digital automation.
• Leadership of improvement initiatives—driving compliance, technical excellence, continuous improvement and profitability—while recruiting, setting goals, and managing performance for multi‑functional teams delivering to time, cost and quality standards.

People Leadership & Culture

• Experience coaching and developing Process Execution Team members while fostering an inclusive, safety‑first and innovation‑driven culture.

Desirable Skills/Experience

• Leadership experience in start‑up, scale‑up and operation in one or more of the following areas: monoclonal antibody production, API chemical manufacturing, and sterile filling and lyophilization.
• Technical knowledge and experience in one or more of the following areas: monoclonal antibody production, API chemical manufacturing, and sterile filling and lyophilization, including tech transfer.
• Experience with digital manufacturing systems such as MES, electronic batch records and data historians.
• Formal Lean, Six Sigma or similar continuous improvement certification.
• Proven track record preparing for and hosting regulatory inspections
• Experience managing operating budgets and capital projects in a regulated manufacturing setting.

Why AstraZeneca

Join a science‑led company where your decisions in the plant directly influence medicines reaching patients sooner. You will work with curious, supportive colleagues who combine rigor with imagination, using data, digital tools and hands‑on collaboration to solve real manufacturing challenges. We value ambition alongside kindness, and we recognize those who take smart risks and turn ideas into measurable results. Here, unexpected teams come together to unlock better ways of working, with constructive coaching, recognition and the resources to scale what works—so your impact grows as our pipeline grows.

Call to Action

Step into a role where you will design, build and lead a high‑performing Drug Substance operation—send your CV today and shape how life‑changing medicines are made!

Date Posted

22-Jan-2026

Closing Date

28-Jan-2026

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry‑leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non‑discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.