Senior Scientist I - Protein Characterisation & Mass Spec

IMMUNOCORE LTD; Broad Blunsdon; On-site; GBP 65,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I to join the Characterisation team within CMC in Oxford. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry to characterise recombinant proteins and antibodies, including glycosylation analysis and PTMs.

You will support drug substance/product impurity characterisation, process development, and contribute to method development for ImmTAX programs. Strong bench skills and collaboration across teams are essential.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.
• Experienced in assay development.

Responsibilities

• Characterise biopharmaceuticals using peptide mapping (LC-MS/MS) and mass spectrometry.
• Support impurity characterisation for drug substance and product.
• Identify protein sequence and post-translational modifications, including glycosylation.
• Characterise process intermediates to support drug substance/product development.
• Contribute to method development for ImmTAX and related products.
• Plan and perform biochemical characterisation, stability and comparability studies.
• Record data and prepare reports; mentor colleagues and share knowledge.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Team mentoring

Mammalian expression

Microbial expression

Education

BSc or MSc in biochemistry or related

Desirable: PhD

Tools

LC-MS/MS

HPLC

GMP familiarity

Job description

Immunocore is seeking a Senior Scientist I to join the Characterisation team within CMC in Oxford. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry to characterise recombinant proteins and antibodies, including glycosylation analysis and PTMs.

You will support drug substance/product impurity characterisation, process development, and contribute to method development for ImmTAX programs. Strong bench skills and collaboration across teams are essential.