Senior Scientist I, Protein Characterisation

IMMUNOCORE LTD; Lower Lemington; On-site; GBP 60,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I focused on Characterisation within CMC in Oxford. You will develop and apply peptide mapping (LC-MS/MS) and intact mass spectrometry analyses to characterise biopharmaceuticals and antibodies.

You will lead experimental studies, contribute to method development for ImmTAX products, and mentor junior scientists while ensuring GMP-aligned documentation and high-quality data generation for regulatory submissions.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry.
• Experienced in assay development.

Responsibilities

• Characterise biotherapeutics using LC-MS/MS and intact mass analyses.
• Support drug substance/product impurity characterisation and identification.
• Perform glycosylation analysis of proteins/antibodies.
• Characterise process intermediates to support development.
• Develop characterisation methods for ImmTAX products and others.
• Design and conduct biochemical characterisation and stability studies.

Skills

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

HPLC methods

Protein expression (microbial & mammal

Education

BSc/MSc in biochemistry/biotechnology

PhD desirable

Tools

LC-MS/MS

HPLC

Job description

Immunocore is seeking a Senior Scientist I focused on Characterisation within CMC in Oxford. You will develop and apply peptide mapping (LC-MS/MS) and intact mass spectrometry analyses to characterise biopharmaceuticals and antibodies.

You will lead experimental studies, contribute to method development for ImmTAX products, and mentor junior scientists while ensuring GMP-aligned documentation and high-quality data generation for regulatory submissions.