Senior Scientist, Biopharma Characterisation & Mass Spec

IMMUNOCORE LTD; West Wycombe; On-site; GBP 55,000 - 75,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I - Characterisation to join its CMC team in the Oxford area. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry methods to characterise biopharmaceuticals, assess glycosylation, and support drug substance/product impurity work.

You will coordinate extensive testing, mentor colleagues, and contribute to study protocols and reports, ensuring high-quality data generation and robust scientific reporting.

Qualifications

• Experience in development of HPLC-based peptide mapping methods and MS characterisation of recombinant proteins or antibodies.
• Glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in characterisation of proteins expressed in microbial and mammalian systems.
• Understanding of post-translational modifications in biological systems.
• Bench-based biopharmaceutical laboratory experience.
• Expertise in electrophoretic, chromatographic or mass spectrometry analyses.

Responsibilities

• Characterise biopharmaceuticals using LC-MS/MS and related methods.
• Support impurity characterisation and identification for drug substance and products.
• Contribute to development of characterisation methods for ImmTAX and other products.
• Design and perform biochemical characterisation, stability and comparability studies.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Education

Biochemistry/ biotechnology degree

PhD (Desirable)

Job description

Immunocore is seeking a Senior Scientist I - Characterisation to join its CMC team in the Oxford area. The role focuses on developing and applying peptide mapping (LC-MS/MS) and mass spectrometry methods to characterise biopharmaceuticals, assess glycosylation, and support drug substance/product impurity work.

You will coordinate extensive testing, mentor colleagues, and contribute to study protocols and reports, ensuring high-quality data generation and robust scientific reporting.