Senior Scientist I - Protein Characterisation & MS

IMMUNOCORE LTD; Christmas Common; Sur place; GBP 65 000 - 90 000; Plein temps

Résumé du poste

Immunocore is seeking a Senior Scientist I - Characterisation to advance protein characterisation methods for biotherapeutics. The role focuses on peptide mapping (LC-MS/MS), intact mass analysis, and analytical characterisation of products across microbial and mammalian expression systems.

The successful candidate will contribute to method development, evaluate post-translational modifications, and collaborate within a matrix team to support process development and quality systems.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.

Responsabilités

• Characterise biotherapeutic proteins using peptide mapping (LC-MS/MS) and mass spectrometry.
• Support impurity characterisation and identification for drug substance and drug product.
• Contribute to development of characterisation methods for ImmTAX and related products.
• Lead biophysical and biochemical characterisation studies and write study protocols/reports.

Connaissances

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Formation

BSc or MSc in biochemistry/biotechnology

PhD (desirable)

Outils

LC-MS/MS

HPLC

Description du poste

Immunocore is seeking a Senior Scientist I - Characterisation to advance protein characterisation methods for biotherapeutics. The role focuses on peptide mapping (LC-MS/MS), intact mass analysis, and analytical characterisation of products across microbial and mammalian expression systems.

The successful candidate will contribute to method development, evaluate post-translational modifications, and collaborate within a matrix team to support process development and quality systems.