Senior Scientist I, Protein Characterisation & Mass Spectrometry

IMMUNOCORE LTD; Letcombe Regis; Presencial; GBP 65 000 - 90 000; Tempo integral

Resumo da oferta

Immunocore, a pioneering biotherapy company, seeks a Senior Scientist I to drive characterisation of biopharmaceuticals, including peptide mapping and mass spectrometry, for ImmTAX programs. You will work across analytical methods, develop and validate HPLC-based peptide mapping, and contribute to impurity and modification analyses in a GMP-like environment.

The role requires hands-on bench work in a biopharma lab, good collaborative skills, and the ability to interpret complex data to inform

Qualificações

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in one or more of the following areas: electrophoretic, chromatographic, mass spectrometry
• Experienced in assay development
• Familiar with biopharmaceutical stability study principles and interpretation thereof
• Worked and contributed actively in a diverse team environment
• Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
• Presented detailed scientific findings and papers to internal and external audiences

Responsabilidades

• Supporting drug substance and drug product impurity characterisation and identification
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
• Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department. May also act as a mentor to other colleagues, sharing scientific knowledge. Providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the department.
• Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
• Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively.
• Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
• Adhere to safe working practices in laboratories according to Immunocore EHS policies.

Conhecimentos

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Post-translational modifications

Bench biopharma lab

Chromatography

Electrophoretic analysis

Assay development

Biopharma stability studies

Team collaboration

Data interpretation

Scientific reporting

Formação académica

BSc/MSc in biochemistry/biotechnology or related

PhD in related discipline

Descrição da oferta de emprego

Immunocore, a pioneering biotherapy company, seeks a Senior Scientist I to drive characterisation of biopharmaceuticals, including peptide mapping and mass spectrometry, for ImmTAX programs. You will work across analytical methods, develop and validate HPLC-based peptide mapping, and contribute to impurity and modification analyses in a GMP-like environment.

The role requires hands-on bench work in a biopharma lab, good collaborative skills, and the ability to interpret complex data to inform