Senior Scientist I, Protein Characterisation & MS

IMMUNOCORE LTD; Middleton Stoney; On-site; GBP 45,000 - 65,000; Full time

Job summary

Immunocore Ltd in the United Kingdom is seeking a Senior Scientist I to characterise biopharmaceutical products, focusing on peptide mapping (LC-MS/MS) and mass spectrometry. You will advance characterisation methods for ImmTAX and other products, while supporting impurity identification and process development in a bench Biotech setting.

The role requires expertise in HPLC-based peptide mapping, MS-based characterisation, and glycosylation analysis, with experience across microbial and

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.

Responsibilities

• Characterisation of biopharmaceutical products including peptide mapping (LC-MS/MS) and intact mass analysis.
• Support drug substance/product impurity characterisation and identification.
• Contribute to development of characterisation methods for ImmTAX and other products.
• Design and perform biochemical characterisation, stability and comparability studies.
• Assist in writing study protocols and reports.

Skills

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Assay development

Biopharmaceutical labs

Education

BSc or MSc in Biochemistry/Biotechnology

PhD in related discipline

Tools

HPLC

Mass spectrometry

Job description

Immunocore Ltd in the United Kingdom is seeking a Senior Scientist I to characterise biopharmaceutical products, focusing on peptide mapping (LC-MS/MS) and mass spectrometry. You will advance characterisation methods for ImmTAX and other products, while supporting impurity identification and process development in a bench Biotech setting.

The role requires expertise in HPLC-based peptide mapping, MS-based characterisation, and glycosylation analysis, with experience across microbial and