Senior Scientist I - Protein Characterisation & MS

IMMUNOCORE LTD; Heath and Reach; On-site; GBP 52,000 - 78,000; Full time

Job summary

Immunocore is a pioneering biopharma company focused on engineered TCR therapies. We are seeking a Senior Scientist I to lead characterisation efforts for biotherapeutics and associated products at our Oxford site.

You will drive peptide mapping, mass spectrometry analyses and PTM characterisation, while collaborating across development teams to advance drug substance and process intermediates. Strong communication and mentoring are required.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in one or more of the following areas: electrophoretic, chromatographic, mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Characterise drug substance and drug product using protein characterisation techniques.
• Perform peptide mapping (LC-MS/MS) and intact mass analysis.
• Identify protein sequence and post-translational modifications incl. glycosylation.
• Support process development through characterisation of intermediates.
• Develop and refine analytical methods for ImmTAX and related products.
• Provide technical guidance and mentoring within the team.
• Maintain rigorous laboratory record-keeping and compliance with EHS policies.
• Communicate results to colleagues, management and partners.

Skills

Peptide mapping

Mass spectrometry

Protein characterisation

Glycosylation analysis

Assay development

Protein expression systems

PTM analysis

Lab bench work

GMP awareness

Scientific communication

Education

BSc/ MSc in Biochemistry or Biotechnology

PhD in related discipline

Tools

HPLC

Job description

Immunocore is a pioneering biopharma company focused on engineered TCR therapies. We are seeking a Senior Scientist I to lead characterisation efforts for biotherapeutics and associated products at our Oxford site.

You will drive peptide mapping, mass spectrometry analyses and PTM characterisation, while collaborating across development teams to advance drug substance and process intermediates. Strong communication and mentoring are required.