Senior Scientist I - Protein Characterisation & MS

IMMUNOCORE LTD

Lower Heyford

On-site

GBP 55,000 - 70,000

Full time

3 days ago

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Job summary

Immunocore Ltd in the United Kingdom is seeking a Senior Scientist I - Characterisation to advance biotherapeutic characterisation for ImmTAX products. You will develop peptide mapping methods (LC-MS/MS), perform mass spectrometry and PTM analyses, and support impurity characterisation.

You will work in a bench-based biopharmaceutical environment, collaborating across teams to drive method development and ensure assay quality, with opportunities to mentor others and present findings.

Qualifications

Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
Experience of glycosylation analysis of recombinant proteins or antibodies.
Independently coordinated extensive testing of protein biomolecules.
Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
Understanding of expected post-translational modifications in biological systems.
Worked in a bench-based biopharmaceutical laboratory environment.
Established as an expert amongst peers in one or more of the following areas: electrophoretic, chromatographic, mass spectrometry
Experienced in assay development
Familiar with biopharmaceutical stability study principles and interpretation thereof
Worked and contributed actively in a diverse team environment
Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
Presented detailed scientific findings and papers to internal and external audiences
Desirable: Glycosylation analysis of recombinant proteins or antibodies
Desirable: Late stage/commercial biopharmaceutical assay development and characterisation
Desirable: Good Manufacturing Practise (GMP) knowledge
Desirable: External conference presentations
Desirable: Led a small project team through change in practice

Responsibilities

Characterise biotherapeutic recombinant T-cell receptor based molecules using protein characterisation and mass spectrometry.
Support drug substance and drug product impurity characterisation and identification
Perform protein sequence and post-translational modification identification, including glycosylation analysis.
Support drug substance and drug product process development by characterisation of process intermediates
Contribute to development of characterisation methods including peptide mapping (LC-MS/MS) and intact mass analysis
Design and carry out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
Contribute to writing study protocols and reports.
Independently testing and leading lines of investigation; proposing new experiments based on emerging data and other related information.
Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department; may mentor others.
Laboratory records: ensuring records are up to date and recorded to standard.
Laboratory equipment: providing technical guidance to others on equipment usage.
Reporting: communicating findings at meetings with colleagues, senior management and partners.
Adhere to safe working practices in laboratories according to EHS policies.