Senior Scientist I, Biopharma Characterisation & Mass Spec

IMMUNOCORE LTD; Preston Capes; On-site; GBP 60,000 - 85,000; Full time

Job summary

Immunocore Ltd in the United Kingdom seeks a Senior Scientist I - Characterisation to advance peptide mapping (LC-MS/MS) and mass spectrometry for biopharmaceutical products.

You will lead impurity characterisation, glycosylation analysis, and post-translational modification profiling for recombinant proteins expressed in microbial and mammalian systems, contributing to method development and product characterization.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experience in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.

Responsibilities

• Characterise proteins using LC-MS/MS peptide mapping and mass spectrometry to support biopharmaceutical products.
• Perform impurity characterisation and identification for drug substances and drug products.
• Contribute to development of characterisation methods for ImmTAX and related products.
• Design and carry out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, when appropriate, leading lines of investigation; provide technical support to others.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Post-translational modification

Assay development

Bench-based biopharmaceutical lab

Experimental design

Team collaboration

Biopharmaceutical testing

Education

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline (desirable)

Job description

Immunocore Ltd in the United Kingdom seeks a Senior Scientist I - Characterisation to advance peptide mapping (LC-MS/MS) and mass spectrometry for biopharmaceutical products.

You will lead impurity characterisation, glycosylation analysis, and post-translational modification profiling for recombinant proteins expressed in microbial and mammalian systems, contributing to method development and product characterization.