Senior Scientist I - Protein Characterisation

IMMUNOCORE LTD; Clifton Hampden; On-site; GBP 65,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I to advance characterisation of biopharmaceuticals, including peptide mapping and mass spectrometry. The role focuses on impurity analysis, PTMs, and method development for ImmTAX and related products, with cross-functional collaboration across R&D teams.

The candidate will perform complex analyses, mentor colleagues, and contribute to study protocols while adhering to EHS standards in a bench-based biopharma setting.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices to improve efficiency.
• Presented detailed scientific findings to internal and external audiences.

Responsibilities

• Characterise drug substance and drug product impurity characterisation and identification.
• Perform protein sequence and post translational modification identification, including glycosylation analysis.
• Support drug substance and drug product process development by characterisation of process intermediates.
• Develop characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Design and carry out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently test and, increasingly, lead lines of investigation; propose new experiments based on emerging data; provide technical support.
• Set priorities for own work and team-based projects using evidence and experience.
• Share knowledge across the department; mentor colleagues; evaluate new techniques to advance the company.
• Maintain up-to-date laboratory records and ensure correct documentation.
• Provide technical guidance on laboratory equipment use.
• Report findings in meetings with colleagues, senior management and partners.
• Adhere to safe working practices in laboratories per EHS policies.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein biomolecule testing

Protein characterization

Post-translational modifications

Bench-based biopharma work

Electrophoretic/Chromatographic/MS

Assay development

Team collaboration & mentoring

Scientific communication

Education

BSc or MSc in biochemistry/biotechnology

Desirable: PhD in related discipline

Job description

Immunocore is seeking a Senior Scientist I to advance characterisation of biopharmaceuticals, including peptide mapping and mass spectrometry. The role focuses on impurity analysis, PTMs, and method development for ImmTAX and related products, with cross-functional collaboration across R&D teams.

The candidate will perform complex analyses, mentor colleagues, and contribute to study protocols while adhering to EHS standards in a bench-based biopharma setting.