Senior Characterisation Scientist – Biologics & Mass Spec

IMMUNOCORE LTD; Lillingstone Dayrell; Presencial; GBP 65.000 - 90.000; Jornada completa

Descripción de la vacante

Immunocore is seeking a Senior Scientist I - Characterisation to advance the analytical characterisation of biotherapeutics. You will apply HPLC-based peptide mapping and mass spectrometry to understand product quality and post-translational modifications, supporting drug substance and product impurity analysis.

In this role, you will develop and implement characterisation methods for ImmTAX and related products, coordinate experiments, mentor colleagues, and communicate complex data to senior

Formación

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.

Responsabilidades

• Characterise biotherapeutics using peptide mapping (LC-MS/MS) and intact mass analysis.
• Support drug substance and product impurity characterisation and identification.
• Contribute to development of characterisation methods for ImmTAX products.
• Design and perform biochemical characterisation, stability and comparability studies.
• Present findings to internal teams and external partners.

Conocimientos

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Biopharmaceutical lab experience

Educación

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Herramientas

LC-MS/MS

HPLC

Mass spectrometry

Descripción del empleo

Immunocore is seeking a Senior Scientist I - Characterisation to advance the analytical characterisation of biotherapeutics. You will apply HPLC-based peptide mapping and mass spectrometry to understand product quality and post-translational modifications, supporting drug substance and product impurity analysis.

In this role, you will develop and implement characterisation methods for ImmTAX and related products, coordinate experiments, mentor colleagues, and communicate complex data to senior