Senior Scientist, Biopharma Characterisation & MS

IMMUNOCORE LTD; Princes Risborough; On-site; GBP 70,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I in Characterisation within CMC to advance biopharmaceutical product analysis, including peptide mapping and mass spectrometry. You will support impurity characterisation, process development, and method development for ImmTAX and related products, collaborating with cross-functional teams.

The role requires bench expertise in protein analysis, glycosylation studies, and PTMs, with opportunities to mentor colleagues and contribute to reports and study

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.

Responsibilities

• Characterisation of biopharmaceutical products including peptide mapping (LC-MS/MS) and intact mass analysis.
• Support drug substance and drug product impurity characterisation and identification.
• Design and carry out biochemical characterisation, chemical stability and comparability studies.
• Contribute to writing study protocols and reports.
• Mentor colleagues and share technical knowledge across the department.
• Present detailed scientific findings and papers to internal and external audiences.

Skills

Experiment design

Independent testing

Team collaboration

Scientific reporting

Education

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Tools

HPLC peptide mapping

Mass spectrometry characterization

Glycosylation analysis

Protein/antibody characterization techniques

Job description

Immunocore is seeking a Senior Scientist I in Characterisation within CMC to advance biopharmaceutical product analysis, including peptide mapping and mass spectrometry. You will support impurity characterisation, process development, and method development for ImmTAX and related products, collaborating with cross-functional teams.

The role requires bench expertise in protein analysis, glycosylation studies, and PTMs, with opportunities to mentor colleagues and contribute to reports and study