Senior Scientist I - Protein Characterisation & Mass Spec

IMMUNOCORE LTD; Chipping Warden; On-site; GBP 70,000 - 90,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I to advance characterisation work for biopharmaceutical products in Oxford. You will develop LC-MS/MS peptide mapping methods, analyse glycosylation, and independently coordinate extensive biomolecule testing across microbial and mammalian systems.

The role requires hands-on lab work, collaboration across teams, and contribution to method development and reports. You will mentor peers and help drive efficient, compliant characterisation workflows within

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in one or more of the following areas: o electrophoretic o chromatographic o mass spectrometry
• Experienced in assay development
• Familiar with biopharmaceutical stability study principles and interpretation thereof
• Worked and contributed actively in a diverse team environment
• Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
• Presented detailed scientific findings and papers to internal and external audiences

Responsibilities

• Characterise proteins using LC-MS/MS and peptide mapping.
• Support impurity characterisation of drug substance and drug product.
• Identify post-translational modifications including glycosylation.
• Develop characterisation methods for ImmTAX and other products.
• Design and carry out biochemical characterisation and stability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Mentor colleagues and share knowledge; present findings to teams and partners.

Skills

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterization

Assay development

Biopharmaceutical lab experience

Electrophoretic

Chromatographic

Mammalian expression

Data presentation

Education

BSc/MSc in biochemistry or related

PhD (desirable)

Job description

Immunocore is seeking a Senior Scientist I to advance characterisation work for biopharmaceutical products in Oxford. You will develop LC-MS/MS peptide mapping methods, analyse glycosylation, and independently coordinate extensive biomolecule testing across microbial and mammalian systems.

The role requires hands-on lab work, collaboration across teams, and contribution to method development and reports. You will mentor peers and help drive efficient, compliant characterisation workflows within